Adjunctive glucose-lower therapies do not decrease risk of microvascular complications in diabetic patients
1. No significant differences in vascular complications of diabetes were seen in patients using...
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chronic-disease
Factors associated with anticoagulation discontinuation in palliative care patients
1. The decision to discontinue anticoagulation in palliative care patients was not strongly...
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Roflumilast cream superior to vehicle cream in the treatment of plaque psoriasis – the DERMIS-1 and DERMIS-2 trials
1. Treatment of plaque psoriasis with roflumilast cream was associated with better clinical...
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Risk of hip fracture in meat-eaters, pescatarians, and vegetarians
1. In a cohort of UK-based women, vegetarians/vegans, but not occasional meat-eaters or...
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Regular physical activity may confer protection against adverse COVID-19 outcomes
1. In this study, engaging in regular physical activity had a lower risk of infection,...
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Selpercatinib continues to demonstrate effective response in RET fusion-positive NSCLC
1. Selpercatinib was found to have similar effective objective response rates compared to past...
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Selpercatinib showed promising clinical activity in tumour-agnostic patients with RET fusion-positive cancers other than thyroid and lung cancer
1. Objective response rate was 43.9%. Patients treated with selpercatinib also experienced...
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Glargine and liraglutide are effective glucose-lowering medications in type 2 diabetes
1. Compared to sitagliptin and glimepiride, glargine and liraglutide were more effective in...
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More permissive parameters for active surveillance eligibility is potentially possible in slow-growing thyroid cancers
1. Patients in the active surveillance group who had forgone surgery had no difference in survival...
Read MoreIncreased pre-chemotherapy inflammatory biomarkers (IL-6 and CRP) correlated to increased risk of frailty post-chemotherapy in older breast cancer patients
1. 25.8% of patients receiving chemotherapy for breast cancer experienced worsening frailty status. 2. Patients with both biomarkers (IL-6 and CRP) elevated before chemotherapy had a significantly higher risk of decline in...
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Dapagliflozin slows disease progression in patients with heart failure with preserved ejection fraction
1. Dapagliflozin was shown to reduce the risk of disease progression and cardiovascular death in...
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Tofersen does not improve ALS symptoms in patients with SOD1 mutations
1. In patients with amyotrophic lateral sclerosis (ALS) and superoxide dismutase 1 (SOD1)...
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Effectiveness of stand-alone telephone-delivered intervention for reducing problem alcohol use
1. In this randomized controlled trial, in participants with problem alcohol use, individuals in...
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Occupational and leisure physical activity may have varying effects on inflammation
1. Lower leisure time physical activity and higher occupational physical activity were associated...
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Unsupervised online yoga transiently improves symptoms in patients with knee osteoarthritis
1. Compared to a control group, patients with knee osteoarthritis who engaged in online yoga had...
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Dupilumab plus topical corticosteroids are effective in the treatment of childhood atopic dermatitis
1. By week 16, 28% of patients in dupilumab reported clear or almost clear skin (IGA 0-1) compared...
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Lower limb osteoarthritis may be more prevalent in retired Olympians
1. In this study, one in four retired Olympians reported physician-diagnosed osteoarthritis (OA),...
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Risk of cardiovascular pathology determined using advanced cardiovascular imaging limited by heterogeneity amongst patients with human immunodeficiency virus
1. Prevalence of moderate coronary disease ranged from 0-52% amongst patients with human...
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Sleep surgery for obstructive sleep apnea may decrease blood pressure
1. In this systematic review and meta-analysis, surgeries for sleep apnea showed improvements in...
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Adjuvant pembrolizumab increased disease-free survival in completely resected, PD-L1 unselected non-small-cell lung cancer patients
1. Adjuvant pembrolizumab significantly improved disease-free survival in comparison to placebo in...
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