Preclinical detectable phase for open-angle glaucoma estimated at 10 years
1. Based on a large Swedish cohort screened for open-angle glaucoma, the estimated preclinical...
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chronic-disease
Overall survival with triplet therapy in BRAF V600 mutation-positive advanced melanoma
1. OS in triplet combination therapy (atezolizumab, vemurafenib, and cobimetinib) while numerally...
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Maternal anemia in pregnancy may be associated with subsequent brain structure changes in offspring
1. Anemia during pregnancy associated with altered brain structure in children including smaller...
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Religion and spirituality dimensions may be beneficial in bipolar disorder symptoms
1. In this scoping review, intrinsic religiosity and positive religious coping are the dimensions...
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Pemafibrate does not lower cardiovascular risk in individuals with hypertriglyceridemia
1. In patients with type 2 diabetes and hypertriglyceridemia, pemafibrate did not alter the...
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No difference in clinical outcomes between joint replacement and fusion surgeries for ankle osteoarthritis
1. In patients with end-stage ankle osteoarthritis, no differences were seen in outcomes between...
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SGLT2 inhibitors reduce the risk of kidney disease in patients with and without diabetes
1. SGLT2 inhibitors reduced the risk of kidney disease progression by 37% overall, with comparable...
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Self-monitoring of physical activity may be enhanced through additional interventions
1. In this systematic review and meta-analysis, prescribed goal and human counseling increased...
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Low-dose low-molecular weight heparin comparable to intermediate-dose for risk of venous thromboembolism in peripartum women
1. Risk of venous thromboembolism in the antepartum and postpartum period was comparable between...
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Personalized cooler dialysate does not reduce cardiovascular events for hemodialysis patients
1. There was no significant difference in the risk of cardiovascular-related death or...
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Various single and multistructure knee injuries increase the odds of knee osteoarthritis
1. In this systematic review and meta-analysis, moderate certainty evidence suggested that damage...
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Vitamin D supplementation is not preventative for statin-associated muscle symptoms or statin discontinuation
1. A randomized controlled trial found that pretreatment with supplemental vitamin D did not...
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Regular physical activity may improve vaccine effectiveness against COVID-19 outcomes
1. In this South African case-control study, there was an inverse dose-response association with...
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Olpasiran significantly reduces lipoprotein(a) levels in patients with cardiovascular disease
1. Olpasiran significantly and substantially reduced lipoprotein(a) concentration in patients with...
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ENT-01 reduces rates of constipation in patients with Parkinson’s disease
1. In comparison to placebo, ENT-01 increased rates of complete spontaneous bowel movements per...
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Bariatric surgery may provide benefit in treating obstructive sleep apnea
1. In this pre-/post- cohort study, patients undergoing bariatric surgery had increased airway...
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Early mobilization after ICU mechanical ventilation does not improve survival
1. Early mobilization of patients after mechanical ventilation in the intensive care unit (ICU)...
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Very low-fat diet may be associated with increased glaucoma risk
1. In a secondary analysis of a large, randomized low-fat dietary modification trial in...
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Accuracy and clinical utility of obstructive sleep apnea screening tools uncertain in primary care settings – US Preventive Services Task Force
1. Positive airway pressure was associated with a significant improvement in Epworth sleepiness...
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Long COVID syndrome may be associated with insomnia and excessive sleepiness
1. In this prospective cohort study, a high prevalence of sleep symptoms were identified in a...
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