Genome-wide analysis aids in diagnosing rare pediatric diseases
Bookmark1. In this cohort study, a combination of exome sequencing, microarray analysis, and...
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chronic-disease
Minimum unit pricing on alcohol is associated with reductions in alcohol-related hospitalizations and mortality
Bookmark1. Mortality attributable to alcohol consumption was reduced by 13.4% while...
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Venetoclax in addition to ibrutinib effective as a treatment for chronic lymphocytic leukemia
Bookmark1. High genetic risk participants with chronic lymphocytic leukemia (CLL) taking...
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Benign hysterectomy with ovarian removal is not associated with clear survival benefit
Bookmark1. In this population-based cohort study, compared to women without bilateral...
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Endovascular therapy improved clinical outcomes among patients 6-24 hours post-ischemic stroke with collateral flow
Bookmark1. Median modified Rankin Scale score at 90 days was lower in the endovascular group,...
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Vitamin K2 supplementation may improve outcomes in patients with Type 2 Diabetes
Bookmark1. This double-blind 1:1 randomized control trial of vitamin K2 administration for type 2...
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DVD and telephone-based interventions effective to increase rates of cancer screening in rural areas
Bookmark1. For female patients living in rural areas, an interactive DVD intervention and...
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Combination therapy is more effective than sleep position device or oral appliance therapy alone in treating positional obstructive sleep apnea
Bookmark1. In this randomized controlled trial, the combination of an eye mask sleep position...
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Measuring the rate of change of breast density over time may help to refine breast cancer screening
Bookmark1. A significantly slower rate of breast density decline over time was observed in the...
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Adagrasib in Advanced Solid Tumors Harboring a KRASG12C Mutation
Bookmark1. The overall objective response rate was 35.1% in patients with initial measurable...
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Sound and light interventions improve sleep in critically ill patients
Bookmark1. In this systematic review and meta-analysis, it was found that among critically ill...
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Cesarean delivery may be associated with increase odds of developing early-onset colorectal cancer in women
Bookmark1. In a case-control study based in Sweden, females born by C-section had greater odds of...
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Physical activity interventions may improve symptom resolution in children following concussion
1. In a systematic review and meta-analysis of interventions following concussion in children,...
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Bempedoic acid reduces the risk of major adverse cardiovascular events
1. In this randomized controlled trial, bempedoic acid significantly reduced low-density...
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Sotatercept improves outcomes in patients with pulmonary arterial hypertension
1. Among patients on stable therapy for pulmonary arterial hypertension (PAH), sotatercept...
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The Medical Outcomes Short Form 12 questionnaire is often used in patients with type 2 diabetes
1. In this systematic review, the most common validated questionnaire used to evaluate the quality...
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Dersimelagon reduces symptomatic disease in erythropoietic protoporphyrias
1. In this randomized controlled trial, oral dersimelagon resulted in significantly increased time...
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Stereotactic radiosurgery did not outperform conventional external beam radiotherapy in patients with localized vertebral metastatic lesions
1. Pain response at 3 months post-treatment show no advantage of stereotactic radiosurgery vs....
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Long-Term Outcomes of Sotorasib in KRAS-G12C Non–Small-Cell Lung Cancer
1. Sotorasib showed prolonged efficacy with a median OS of 12.5 months (33% at 24 months) and an...
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Donor sex has no effect on survival in patients receiving red blood cell transfusions
1. In this randomized controlled trial, donor sex did not result in a significant difference in...
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