Orforglipron may be a safe and effective oral GLP-1 agonist for treatment of type 2 diabetes
Bookmark1. Patients assigned to orforglipron experienced significant reductions in HbA1c, and body...
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chronic-disease
Atezolizumab monotherapy superior to chemotherapy for treatment of non-small cell lung cancer
Bookmark1. Median overall survival in the atezolizumab group was 10.3 months versus 9.2 months in...
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Perioperative Nivolumab and Chemotherapy in Stage III NSCLC
Bookmark1. The pathological complete response rate for the experimental group was improved...
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The addition of neoadjuvant and adjuvant pembrolizumab to standard chemotherapy and surgery may improve outcomes in patients with early-stage non-small cell lung cancer
Bookmark1. At 24 months, more participants in the pembrolizumab group were alive without an event,...
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Abatacept, cenicriviroc, or infliximab does not decrease time to recovery for hospitalized patients with COVID-19 pneumonia
Bookmark1. There was no statistically significant difference in recovery time in patients with...
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Mental health disorders more prevalent amongst adults with inflammatory skin conditions
Bookmark1. Anxiety and depression were more prevalent among individuals with eczema or psoriasis,...
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CSF1R regulates schizophrenia-related stress response and vascular association of microglia/macrophages
Bookmark1. Compared to healthy controls, participants with a first episode of schizophrenia had...
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Dupilumab reduces the number exacerbations in patients with COPD and type two inflammation
Bookmark1. In this randomized controlled trial, dupilumab use was associated with significantly...
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Dupilumab For Management of Bullous Pemphigoids
Bookmark1. Dupilumab treatment for bullous pemphigoids resulted in improved clinical symptoms. 2....
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School-based water promotion program associated with lower overweight prevalence
Bookmark1. Implementation of ‘Water First’, a program consisting of classroom lessons, water...
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Zilebesiran improves blood pressure management in patients with hypertension
Bookmark1. In this randomized controlled trial, zilebesiran resulted in reduced serum...
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Opioid analgesia may be ineffective for acute low back and neck pain
Bookmark1. Mean pain score at 6 weeks was not statistically different between the opioid and...
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Mortality rates among patients successfully treated for hepatitis C still higher than the general population
Bookmark1. Among those treated for Hepatitis C Virus (HCV) infection, leading causes of death...
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Long-acting antiretroviral therapy injections maintain viral suppression in people living with HIV
Bookmark1. In this observational study, long-acting antiretroviral therapy (LA-ART) was effective...
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Talazoparib plus enzalutamide improves progression-free survival in metastatic prostate cancer
Bookmark1. Progression-free survival was significantly higher in the talazoparib plus enzalutamide...
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Reducing the screening age for colorectal cancer in Canada to 40 or 45 may result in fewer cases, less mortality, and reduced healthcare spending costs
Bookmark1. Initiating colorectal cancer screening at age 45 results in 12,188 fewer cases and...
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Integrated Clinical-Molecular Classification of Colorectal Liver Metastases
Bookmark1. The immune subtype demonstrated an improved progression-free survival (HR 0.37) and...
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Insulin icodec is more effective than insulin glargine for glycemic control
Bookmark1. In this randomized controlled trial, weekly insulin icodec use resulted in better...
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SGLT2 inhibitors reduce recurrent flares and hospitalizations in patients with gout
Bookmark1. In this population cohort study, patients with gout who used sodium-glucose...
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Social screening in community health clinics does not consistently improve early childhood health
Bookmark1. In a randomized control trial of the social care screening program WE CARE, health...
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