chronic-disease

Updated Outcomes of Sacituzumab Govitecan in Resistant Advanced Urothelial Carcinoma

Feb 6, 2024

1. The objective response rate was 28% with a complete response of 5.6% and a partial response of...

Lower risk of adverse outcomes secondary to hypertension observed at higher ages in elderly

Feb 6, 2024

1. When comparing cohorts of patients above and below 75 years of age, hypertension had a greater...

Small long term increased risks of neurodevelopmental deficits for infants born preterm

Feb 5, 2024

1. Moderately or late preterm infants were found to have an increased risk of neurological...

Urgent need for improved detection of pediatric familial hypercholesterolemia worldwide

Feb 5, 2024

1. 92.4% of children in high-income countries had heterozygous familial hypercholesterolemia...

Maternal autistic traits may be associated with greater risk of adverse birth outcomes

Feb 5, 2024

1. A cohort study found that increased maternal autistic traits were associated with a greater...

Improved long-term survival with resynchronization versus defibrillation for heart failure

Feb 3, 2024

1. In this randomized controlled trial, the incidence of death was lower in heart failure patients...

Acoramidis slows disease progression in transthyretin amyloid cardiomyopathy

Feb 2, 2024

1. In this randomized controlled trial, patients with transthyretin (TTR) amyloid cardiomyopathy...

Atezolizumab in addition to bevacizumab and platinum-based chemotherapy improves survival in metastatic cervical cancer

Feb 1, 2024

1. The Atezolizumab group demonstrated significantly greater progression-free and overall survival...

Worse breast cancer death rates for non-screen detected ductal carcinoma situ

Feb 1, 2024

1. Women with non-screen detected ductal carcinoma in situ had worse outcomes for the 25 years...

Non-invasive ultrasound therapy safely improves aortic valve function in high-risk patients with calcified aortic stenosis

Jan 31, 2024

1. There was no procedure-related mortality or life-threatening events reported. 2. At the 6-month...

Mirtazapine improves caloric intake compared to placebo in patients with advanced non-small cell lung cancer

Jan 30, 2024

1. While perceived appetite did not differ between study groups, patients receiving mirtazapine...

Low dose olanzapine in non-inferior to standard dose in terms of anti-emetic effect in patients receiving emetogenic chemotherapy

Jan 30, 2024

1. Low dose Olanzapine (2.5 mg) demonstrated similar anti-emetic effect to standard dose...

Cemiplimab for Kidney Transplant Recipients With Cutaneous Squamous Cell Carcinoma

Jan 30, 2024

1. There was no kidney rejection noted in the cemiplimab for kidney transplant recipients. 2....

Ubrogepant is safe and effective for acute treatment of migraine prodrome

Jan 26, 2024

1. Absence of moderate or severe headache 24 hours following administration of treatment drug was...

Risk factors associated with cognitive impairment development in older adults

Jan 25, 2024

1. This longitudinal prospective cohort study found that older adults with trajectories involving...

Pembrolizumab and chemotherapy combination improves survival in advanced pleural mesothelioma

Jan 25, 2024

1. Patients in the pembrolizumab plus chemotherapy group reported a significantly greater overall...

Monocyte-to-HDL ratio may be an indicator of poor endothelial dysfunction in diabetics

Jan 23, 2024

1. This cross-sectional study is the first to identify the monocyte-to-HDL ratio (MHR) as an indicator of poor endothelial dysfunction in a sample of diabetic patients. Evidence Rating Level: 2 (Good) Endothelial disruption and...

Perinatal depression associated with threefold risk of suicidal behaviour

Jan 22, 2024

1. Perinatal depression (PND) was found to be associated with a 3-fold increased risk for suicidal behaviours compared to a non-PND cohort at 18-year follow-up. 2. PND most significantly increased risk for suicidal behaviours...