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Cardiology General

Myeloid-associated lipin-1 transcriptional co-regulatory activity is atheroprotective.

Jul 15, 2021

Atherosclerosis is the most prominent underlying cause of cardiovascular disease (CVD). It is initiated by cholesterol deposition in the arterial intima, which causes macrophage recruitment and proinf...

Cost Conversations About Anticoagulation Between Patients With Atrial Fibrillation and Their Clinicians: A Secondary Analysis of a Randomized Clinical Trial.

Jul 15, 2021

How patients with atrial fibrillation (AF) and their clinicians consider cost in forming care plans remains unknown.To identify factors that inform conversations regarding costs of anticoagulants for ...

In-hospital complications in acute ST-elevation myocardial infarction depending on renal function.

Jul 15, 2021

To analyze in-hospital complications in patients with acute ST-elevation myocardial infarction (STEMI) depending on renal function.Observational study in patients with STEMI.The study included 169 pa...

A Quality Improvement Initiative for Improving Care for Childhood Obesity

Jul 13, 2021

A quality improvement initiative helped pediatric practice sustain improvement in adherence to obesity management recommendations from the American Academy of Pediatrics.   Obesity affe...

Upper extremities deep vein thrombosis treated with oral direct anticoagulants: A prospective cohort study.

Jul 12, 2021

Limited data are available on the role of direct oral anticoagulants (DOACs) for the treatment of upper extremities deep vein thrombosis (UEDVT).The aim of this study was to assess the effectiveness a...

Effect of the oXiris membrane on microcirculation after cardiac surgery under cardiopulmonary bypass: study protocol for a randomised controlled trial (OXICARD Study).

Jul 12, 2021

Cytokine storm and endotoxin release during cardiac surgery with cardiopulmonary bypass (CPB) have been related to vasoplegic shock and organ dysfunction. We hypothesised that early (during CPB) cytok...

Pseudoginsenoside-F11 promotes functional recovery after transient cerebral ischemia by regulating the microglia/macrophage polarization in rats.

Jul 12, 2021

The polarization of microglia/macrophages after cerebral ischemia is critical for post-stroke damage/recovery. Previously, we found that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, has ne...

Effects of peer support interventions on physical and psychosocial outcomes among stroke survivors: A systematic review and meta-analysis.

Jul 12, 2021

High level of unmet needs were reported by stroke survivors after hospital discharge. Peer support interventions may play a valuable role in the management of stroke, but the evidence is unclear.To de...

Complications of tunneled peripherally inserted and tunneled-cuffed central catheters in home parenteral nutrition.

Jul 12, 2021

We sought to compare complications associated with tunneled peripherally inserted central catheters (tPICCs) and tunneled-cuffed centrally inserted central catheters (tCICCs) in adult home parenteral ...

A novel transgenic Cre allele to label mouse cardiac conduction system.

Jul 12, 2021

The cardiac conduction system is a network of heterogeneous cell population that initiates and propagates electric excitations in the myocardium. Purkinje fibers, a network of specialized myocardial c...

Association between acute myocardial infarction and death in 386 patients with a thrombus straddling a patent foramen ovale.

Jul 12, 2021

Right atrial thrombi are rarely found straddling a patent foramen ovale (PFO). A thrombus straddling a PFO (TSPFO), also known as impending paradoxical embolism, is a medical emergency associated with...

Health-related quality of life and incident cardiovascular disease events in community-dwelling older people: A prospective cohort study.

Jul 12, 2021

Lower health-related quality of life (HRQoL) has been shown to predict a higher risk of hospital readmission and mortality in patients with cardiovascular disease (CVD). Few studies have explored the ...

Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension.

Jul 12, 2021

Depressed right ventricular ejection fraction (RVEF) has clear prognostic significance in patients with pulmonary arterial hypertension (PAH). Accordingly, improvements in RVEF represent a desirable e...

BNT162b2 vaccine breakthrough: clinical characteristics of 152 fully-vaccinated hospitalized COVID-19 patients in Israel.

Jul 12, 2021

mRNA COVID-19 vaccines have shown high effectiveness in the prevention of symptomatic COVID-19, hospitalization, severe disease, and death. Nevertheless, a minority of vaccinated individuals might get...

Stage 1 hypertension defined by the 2017 ACC/AHA guidelines and neonatal outcomes: Systematic review and meta-analysis.

Jul 12, 2021

In 2017, the American College of Cardiology/ American Heart Association (ACC/AHA) guidelines redefined the threshold of high blood pressure (BP) for non-pregnant adults. Several studies aimed to deter...

Efficacy of DPP-4 inhibitors and SGLT2 inhibitors compared to sulphonylureas in adult patients with diabetes with low c-peptide levels with or without anti-GAD65 antibody positivity.

Jul 12, 2021

Latent Autoimmune Diabetes of Adulthood (LADA) is different from type 2 diabetes. Present treatment protocols do not reflect that. DPP-4 and SGLT2 inhibitors have changed therapy. DPP-4 inhibitor use ...

Fracture behavior of human cortical bone: Role of advanced glycation end-products and microstructural features.

Jul 12, 2021

Diabetes is associated with increased fracture risk in human bone, especially in the elderly population. In the present study, we investigate how simulated advanced glycation end-products (AGEs) and m...

Syringaldehyde promoting intestinal motility with suppressing α-amylase hinders starch digestion in diabetic mice.

Jul 12, 2021

The antihyperglycemic potential of syringaldehyde has been previously investigated; however, the underlying mechanism remains unclear. In this study, we performed a postprandial glucose test (in vivo)...

Etiology and Treatment Patterns of Ruptured Extracranial Carotid Artery Aneurysm.

Jul 12, 2021

Rupture of an extracranial carotid artery aneurysms (ECAA) is a very rare and life-threatening condition. In order to get a comprehensive view of past and current management of the ruptured ECAA (rECA...

Dietary iron overload mitigates atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice: Role of dysregulated hepatic fatty acid metabolism.

Jul 12, 2021

The atherosclerosis "iron hypothesis" generates a fair amount of debate since it has been proposed. Here, we revisited the "iron hypothesis" by examining whether dietary iron overload would intensify ...