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Cardiology General

Towards Replacing Late Gadolinium Enhancement

Aug 19, 2021

The aim of this study states that Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging is the gold standard for non-invasive myocardial tissue characterization, but requir...

Red Blood Cell and Endothelial eNOS

Aug 19, 2021

This study states that Current paradigms suggest that nitric oxide (NO) produced by endothelial cells (ECs) via endothelial nitric oxide synthase (eNOS) in the vessel wall is the primary regulator of ...

Diagnosis and Management of Myocarditis in Children

Aug 19, 2021

This study statea that Myocarditis remains a clinical challenge in pediatrics. Originally, it was recognized at autopsy before the application of endomyocardial biopsy, which led to a histopathology-b...

MicroRNA-21 Controls Circadian Regulation

Aug 19, 2021

The expression of molecular clock genes, lesional apoptosis, and necrotic core size were diurnally regulated in Apoe-/-mice. Efferocytosis did not match the diurnal increase in apoptosis at the beginn...

Assessing and Addressing Cardiovascular Health

Aug 19, 2021

This study states that There is growing evidence that people who are transgender and gender diverse (TGD) are impacted by disparities across a variety of cardiovascular risk factors compared with thei...

Epigenetic Regulation by Suv4-20h1

Aug 19, 2021

This study states that The etiology of life-threatening cardiopulmonary diseases such as Pulmonary Hypertension (PH) and Chronic Obstructive Pulmonary Disease (COPD) originates from a complex interpla...

Hyperglycaemia Induces Trained Immunity

Aug 19, 2021

This study states that Cardiovascular risk in diabetes remains elevated despite glucose lowering therapies. We hypothesised that hyperglycaemia induces trained immunity in macrophages, promoting persi...

International Observational Analysis of Evolution

Aug 19, 2021

This study states that Although angina is common in patients with stable coronary artery disease (CAD), limited data are available on its prevalence, natural evolution, and outcomes in the era of effe...

Therapeutic Inhibition of Acid Sensing

Aug 19, 2021

This study states that Ischemia-reperfusion injury (IRI) is one of the major risk factors implicated in morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the bui...

An overview of current advancements in pancreatic islet transplantation into the omentum.

Aug 19, 2021

Pancreatic islet transplantation to restore insulin production in Type 1 Diabetes Mellitus patients is commonly performed by infusion of islets into the hepatic portal system. However, the risk of por...

When and how to use direct oral anticoagulants in patients with advanced chronic liver disease?

Aug 19, 2021

Direct oral anticoagulants (DOACs) emerged as effective and safe alternatives to traditional anticoagulants for the prevention and treatment of venous thromboembolic disease and the prevention of stro...

Postoperative Complications Associated with the Choice of Reconstruction in Head and Neck Cancer: An Outcome Analysis of 4,712 Patients from the ACS-NSQIP Database.

Aug 19, 2021

 Microsurgical free flaps have largely supplanted pedicled flaps as the gold standard for head and neck cancer reconstruction. However, incidence of postoperative complications after accounting for ...

Cardiomyocyte microRNA-150 confers cardiac protection and directly represses pro-apoptotic small proline-rich protein 1A.

Aug 19, 2021

MicroRNA-150 (miR-150) is downregulated in patients with multiple cardiovascular diseases and in diverse mouse models of heart failure (HF). MiR-150 is significantly associated with HF severity and ou...

Genetic blockade of lymphangiogenesis does not impair cardiac function after myocardial infarction.

Aug 19, 2021

In recent decades, treatments for myocardial infarction (MI), such as stem and progenitor cell therapy, have attracted considerable scientific and clinical attention but failed to improve patient outc...

Transplantation of 3D bio-printed cardiac mesh improves cardiac function and vessel formation via ANGPT1/Tie2 pathway in rats with acute myocardial infarction.

Aug 19, 2021

A novel tissue engineering strategy using 3D bio-print technology has become a promising therapeutic method for acute myocardial infarction (AMI) in an animal model. However, the application of 3D bio...

Primary adenocarcinoma of the appendix presenting with fresh bleeding per rectum: A case report.

Aug 19, 2021

Primary adenocarcinoma of appendix is a rarely diagnosed malignancy accounting for less than 6% of appendiceal neoplastic lesions and less than 0.5% of all gastrointestinal malignancies. It is mostly ...

Intensive care unit admission for patients with pulmonary hypertension presenting to U.S. Emergency Departments.

Aug 19, 2021

Pulmonary hypertension (PH) is an important contributor to morbidity and mortality in patients seeking emergency care, resulting in high acuity presentations and resource utilization. The objective wa...

In search of pulmonary hypertension treatments: Effect of 17β-estradiol on PGI pathway in human pulmonary artery.

Aug 19, 2021

Prostacyclin (PGI) is synthetized by PGI synthase (PGIS) and induces vasorelaxation via activation of cyclic AMP (cAMP) generating IP-receptor. Several components of the PGI signaling pathway are redu...

Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity.

Aug 19, 2021

Aldehyde dehydrogenase 1A1 (ALDH1A1) plays vital physiological and toxicological functions in many areas, such as CNS, inflammation, metabolic disorders, and cancers. Overexpression of ALDH1A1 has bee...

Impaired brown adipose tissue is differentially modulated in insulin-resistant obese wistar and type 2 diabetic Goto-Kakizaki rats.

Aug 19, 2021

Brown adipose tissue (BAT) is a potential target to treat obesity and diabetes, dissipating energy as heat. Type 2 diabetes (T2D) has been associated with obesogenic diets; however, T2D was also repor...