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Cardiology General

Quantifying the Benefit-Risk Trade-Off for Individual Patients in a Clinical Trial: Principles and Anti-Thrombotic Case Study.

Jan 29, 2024

A treatment's overall favourable benefit-risk profile does not imply that every individual patient will benefit from the treatment. We describe a statistical methodology for quantifying the benefit-ri...

Bayesian Mendelian randomization with an interval causal null hypothesis: ternary decision rules and loss function calibration.

Jan 29, 2024

We enhance the Bayesian Mendelian Randomization (MR) framework of Berzuini et al. (Biostatistics 21(1):86-101, 2018) by allowing for interval null causal hypotheses, where values of the causal effect...

Association between dietary diversity and chronic kidney disease in community-dwelling older adults.

Jan 29, 2024

The present study examined whether dietary diversity is associated with chronic kidney disease (CKD) in community-dwelling older Japanese adults.Participants comprised 8,195 older adults (mean age was...

Effect of Macitentan in Pulmonary Arterial Hypertension and the Relationship Between Echocardiography and cMRI Variables: REPAIR Echocardiography Sub-study Results.

Jan 29, 2024

The aim of this sub-study was to evaluate the relationship between echocardiography (echo) and cardiac magnetic resonance imaging (cMRI) variables and to utilize echo to assess the effect of macitenta...

Is catheter ablation associated with preservation of cognitive function? An analysis from the SAGE-AF observational cohort study.

Jan 29, 2024

To examine the associations between catheter ablation treatment (CA) vs. medical management and cognitive impairment among older adults with atrial fibrillation (AF).Ambulatory patients who had AF, we...

Preventive cardiology for the aging population: how can we better design clinical trials of statins?

Jan 29, 2024

Older adults form a fast-increasing proportion of the world population. However, gains in increasing quantity of life have not been accompanied by similar gains in quality of life. Older people freque...

Association between a polygenic lipodystrophy genetic risk score and diabetes risk in the high prevalence Maltese population.

Jan 29, 2024

Type 2 diabetes (T2DM) is genetically heterogenous, driven by beta cell dysfunction and insulin resistance. Insulin resistance drives the development of cardiometabolic complications and is typically ...

Different drugs in drug-eluting stents for peripheral artery disease: a systematic evaluation and Bayesian meta-analysis.

Jan 29, 2024

Drug-eluting stents (DESs) have become the first-line treatment for symptomatic peripheral arterial disease (PAD). Currently, there are many types of DESs on the market. The same type of DESs has diff...

Education of Patients With Atrial Fibrillation and Evaluation of the Efficacy of a Mobile Virtual Patient Environment: Protocol for a Multicenter Pseudorandomized Controlled Trial.

Jan 29, 2024

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is a leading cause of mortality and morbidity. Patient knowledge about AF and its management is paramount but often limited...

Network analysis of the social media activities around the #TeleCheckAF project.

Jan 29, 2024

TeleCheck-AF is a novel remote on-demand mobile health infrastructure around teleconsultations for patients with atrial fibrillation. Social media (SoMe) communication on Twitter contributed to the di...

Recruiting a Diverse Cardiology Physician Workforce.

Jan 29, 2024

Understanding trends in the representation of women and individuals from underrepresented racial and ethnic populations in cardiovascular disease and cardiovascular subspecialty fellowships is essenti...

The outcome of conversion total hip arthroplasty following acetabular fractures: a systematic review and meta-analysis of comparative studies.

Jan 22, 2024

Conversion total hip arthroplasty (THA) is considered the main treatment plan for patients with first-line treatment failure of acetabulum fracture. This meta-analysis aims to assess the effect of the...

Effects of non-pharmacological interventions on fatigue in people with stroke: a systematic review and meta-analysis.

Jan 22, 2024

Fatigue, a common problem following a stroke, can have negative effects on a person's daily life. There are no good interventions thus far for alleviating fatigue among those affected.This review aime...

Does financial hardship associate with abnormal quantitative myocardial perfusion and major adverse cardiovascular event?

Jan 22, 2024

Data on impact of financial hardship on coronary artery disease (CAD) remain incomplete.Consecutive subjects referred for clinical rest/stress cardiac positron emission tomography (PET) were enrolled....

Cuffless Blood Pressure in clinical practice: challenges, opportunities and current limits.

Jan 22, 2024

Cuffless blood pressure measurement technologies have attracted significant attention for their potential to transform cardiovascular monitoring. This updated narrative review thoroughly examines the...

Ursodeoxycholic Acid-Decorated Zwitterionic Nanoparticles for Orally Liver-Targeted Close-Looped Insulin Delivery.

Jan 22, 2024

Oral insulin therapies targeting the liver and further simulating close-looped secretion face significant challenges due to multiple trans-epithelial barriers. Herein, we designed ursodeoxycholic acid...

Epicardial adipose tissue and subclinical incident atrial fibrillation as detected by continuous monitoring: a cardiac magnetic resonance imaging study.

Jan 22, 2024

Epicardial adipose tissue (EAT) has endocrine and paracrine functions and has been associated with metabolic and cardiovascular disease. This study aimed to investigate the association between EAT, de...

Non-invasive fractional flow reserve estimation using deep learning on intermediate left anterior descending coronary artery lesion angiography images.

Jan 22, 2024

This study aimed to design an end-to-end deep learning model for estimating the value of fractional flow reserve (FFR) using angiography images to classify left anterior descending (LAD) branch angiog...

Adipose tissue-derived metabolite risk scores and risk for type 2 diabetes in South Asians.

Jan 22, 2024

South Asians are at higher risk for type 2 diabetes (T2D) than many other race/ethnic groups. Ectopic adiposity, specifically hepatic steatosis and visceral fat may partially explain this. Our objecti...

Study on the correlation between red cell distribution width, homocysteine, lipoprotein(a), and left atrial diameter in newly diagnosed nonvalvular atrial fibrillation patients.

Jan 22, 2024

This study aims to investigate the correlations between red cell distribution width (RDW), homocysteine (Hcy), lipoprotein(a) [Lp(a)], and left atrial diameter (LAD) measured by echocardiography in ne...