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Cardiology General

Prognosis and Natural History of Conduction System Disease in Patients Undergoing Coronary Angiography.

Jun 18, 2020

Infranodal conduction abnormalities, including right or left bundle branch block bifascicular block, and nonspecific intraventricular conduction block are common electrocardiogram (ECG) abnormalities ...

The Case of Flecainide Toxicity: What to Look for and How to Treat.

Jun 18, 2020

Flecainide is a class Ic antidysrhythmic agent used to prevent and treat both ventricular and supraventricular tachycardias, including atrial fibrillation, atrioventricular nodal re-entrant tachycardi...

An Uncommon Focal Liver Lesion: Intrahepatic Splenosis.

Jun 15, 2020

Multiple focal liver lesions were incidentally detected in a patient screened by ultrasound for a recent diagnosis of lower limb deep vein thrombosis, for which anticoagulation had been initiated. Pas...

Thrombotic complications of COVID-19 may reflect an upregulation of endothelial tissue factor expression that is contingent on activation of endosomal NADPH oxidase.

Jun 15, 2020

The high rate of thrombotic complications associated with COVID-19 seems likely to reflect viral infection of vascular endothelial cells, which express the ACE2 protein that enables SARS-CoV-2 to inva...

Thromboembolic Safety Reporting of Tofacitinib and Baricitinib: An Analysis of the WHO VigiBase.

Jun 15, 2020

The Janus kinase (JAK) inhibitors tofacitinib and baricitinib are new treatments for rheumatic diseases. Recent concerns regarding the risk of thrombosis have led to warnings by competent authorities....

Blood Pressure Classification of 2017 Associated With Cardiovascular Disease and Mortality in Young Chinese Adults.

Jun 15, 2020

The American College of Cardiology/American Heart Association introduced new guidelines for blood pressure (BP) classification in 2017. We explored associations between the newly defined categories an...

The revolution of the anti-diabetic drugs in cardiology.

Jun 15, 2020

Beginning in December 2008, under the auspices of Food and Drug Administration, numerous controlled clinical trial were planned, and in part completed, concerning the cardiovascular (CV) effects of hy...

To whom recommend intensive treatment for hypertension?

Jun 15, 2020

Arterial hypertension is the main identifiable cardiovascular risk factor, and although the benefit of blood pressure reduction is universally acknowledged, the scientific community has long been divi...

Renal ischemia/reperfusion injury: An insight on in vitro and in vivo models.

Jun 15, 2020

Optimal tissue oxygenation is essential for its normal function. Suboptimal oxygenation or ischemia contributes to increased mortalities during various pathological conditions such as stroke, acute ki...

Neuropeptide Y incorporated into PVAX nanoparticle improves angiogenesis in a murine model of myocardial ischemia.

Jun 15, 2020

Neuropeptide-Y (NPY) leads to angiogenesis and remodeling of the ischemic myocardium. The objective of this study is to assess the therapeutic potential of NPY in a model of acute myocardial ischemia ...

Anaemia is associated with severe RBC dysfunction and a reduced circulating NO pool: vascular and cardiac eNOS are crucial for the adaptation to anaemia.

Jun 15, 2020

Anaemia is frequently present in patients with acute myocardial infarction (AMI) and contributes to an adverse prognosis. We hypothesised that, besides reduced oxygen carrying capacity, anaemia is ass...

Resveratrol attenuates angiotensin II-induced cellular hypertrophy through the inhibition of CYP1B1 and the cardiotoxic mid-chain HETE metabolites.

Jun 15, 2020

Several reports demonstrated the direct contribution of cytochrome P450 1B1 (CYP1B1) enzyme and its associated cardiotoxic mid-chain, hydroxyeicosatetraenoic acid (HETEs) metabolites in the developmen...

Blood pressure after follow-up in a stroke prevention clinic.

Jun 15, 2020

In Denmark, 25% of hospital admissions with stroke are recurrent strokes. With thrombolytic treatment, more patients survive with only minor disability. This promising development should be followed u...

Obstructive sleep apnea risk in patients with focal versus generalized epilepsy.

Jun 15, 2020

Obstructive sleep apnea (OSA) is common in patients with epilepsy (PWE), and treatment may improve seizure control. However, OSA is often undiagnosed in PWE, and understanding of the risk profile for ...

Interpregnancy weight change and recurrence of gestational diabetes mellitus: a population-based cohort study.

Jun 15, 2020

To estimate recurrence risk of gestational diabetes mellitus (GDM) by inter-pregnancy weight change.Population-based cohort study.Data from the Swedish (1992-2010) and the Norwegian (2006-2014) Medica...

Low arginine vasopressin levels in patients with diabetes insipidus are not associated with anaemia.

Jun 15, 2020

Arginine vasopressin (AVP) is released upon osmotic stimulation or hypovolemia in order to maintain water balance. A recent study showed a role of AVP in haematopoiesis by stimulating red blood cell p...

Predicting the presence of coronary artery disease by transesophageal echocardiography.

Jun 15, 2020

The accuracy of ultrasound signs as predictors for the presence of coronary artery disease (CAD) has been evaluated extensively in the 1990s and 2000s. Imaging quality has improved tremendously over t...

ENDOTHELIUM-RESTRICTED ENDOTHELIN-1 OVEREXPRESSION IN TYPE-1 DIABETES WORSENS ATHEROSCLEROSIS AND IMMUNE CELL INFILTRATION VIA NOX1.

Jun 15, 2020

NADPH oxidase (NOX) 1 but not NOX4-dependent oxidative stress plays a role in diabetic vascular disease, including atherosclerosis. Endothelin (ET)-1 has been implicated in diabetes-induced vascular c...

Arterial culprit plaque characteristics revealed by magnetic resonance Vessel Wall imaging in patients with single or multiple infarcts.

Jun 15, 2020

To investigate characteristics of intra- and extracranial arterial culprit plaques between patients with single infarct and multiple-infarcts by a head-neck combined high resolution magnetic resonance...

Evaluation of mexiletine effect on conduction delay and bradyarrhythmic complications in patients with myotonic dystrophy type 1 over long-term follow-up.

Jun 15, 2020

Myotonic dystrophy type 1 (DM1) is a multisystemic disorder characterized by progressive cardiac conduction impairment, arrhythmias and sudden death. Mexiletine is a sodium-channel blocker drug used i...