Aug 24, 2020

Primary aldosteronism (PA) occurs in 10%-20% of patients with resistant hypertension. Guidelines recommend adrenal vein sampling (AVS) to identify patients for surgical management. We evaluate the use...

Aug 24, 2020

Emerging evidence supports combining immune checkpoint inhibitors (ICIs) with conventional or targeted therapies to enhance ICI antitumour activity and broaden the spectrum of patients who respond to ...

Aug 24, 2020

We evaluated a rapid chromatographic immunoassay (IgG/IgM antibodies) and an ELISA assay to diagnose COVID-19 in patient sat two Brazilian hospitals.A total of 122 subjects with COVID-19 were included...

Aug 24, 2020

Methods for measuring frailty over-emphasise physical health, and consensus for a more holistic approach is increasing. However, holistic tools have had mixed success in meeting the validation criteri...

Aug 24, 2020

Diabetic cardiomyopathy (DCM) is a distinct form of heart disease caused by diabetes. Lipid accumulation has been reported to present in the hearts of DCM animals, however characterization of disorder...

Aug 24, 2020

N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin-I (cTnI) are biomarkers commonly evaluated in cats with suspected heart disease. Many cats with hypertrophic cardiomyopathy (...

Aug 24, 2020

Microparticles, also termed extracellular vesicles (EVs) are novel candidate markers of platelet activation and ongoing inflammation in vivo. Different subtypes of EVs are released from platelets, end...

Aug 24, 2020

Angiotensin II (Ang II) is an oligopeptide of the renin-angiotensin system, and Ang II-induced vascular smooth muscle cell (VSMC) proliferation is an important pathophysiological process involved in a...

Aug 24, 2020

Diabetes is characterized by changed homeostasis of blood glucose levels, which is associated with various complications, including cardiomyopathy, atherosclerosis, endothelial dysfunction, nephropath...

Aug 24, 2020

BACKGROUNDGenomic and experimental studies suggest a role for PITX2 in atrial fibrillation (AF). To assess if this association is relevant for recurrent AF in patients, we tested whether left atrial P...

Aug 21, 2020

Baroreflex activation therapy (BAT) is a method of treating resistant high blood pressure by using an implanted device to electrically stimulate baroreceptors in the carotid sinus region. This approac...

Aug 21, 2020

Acute coronary syndrome (ACS) is a collective term used to describe conditions associated with a sudden, reduced flow to the heart. Percutaneous coronary intervention (PCI) is a non-surgical procedure...

Aug 21, 2020

Homozygous familial hypercholesterolemia (FH) is a congenital disorder that makes it difficult for your body to remove LDL cholesterol from your blood. Alirocumab is a biopharmaceutical medication app...

Aug 21, 2020

Chronic Aortic Regurgitation (AR), or aortic insufficiency, is the leaking of the aortic valve that causes the blood to flow in the reverse direction during ventricular diastole. Mitral regurgitation ...

Aug 21, 2020

A significant amount of evidence suggests that COVID-19 is associated with cardiovascular disease, with myocarditis being the most common complication. Yet, the magnitude of myocardial injury among pa...

Aug 21, 2020

Nonsteroidal anti-inflammatory drugs (NSAID) are the primary line of treatment after myocardial infarction. However, the risk of adverse clinical events associated with the use of NSAIDs is not well s...

Aug 21, 2020

Transcatheter valve-in-valve aortic valve replacement (VIV TAVR) and redo surgical aortic valve replacement (SAVR) are the two commonly used practiced treatments for aortic bioprosthesis failure, but ...

Aug 21, 2020

Reperfusion is a common complication of acute myocardial infarction (AMI) that is characterized by tissue damage caused when blood supply returns to the tissue. Transvalvuvar ventricle unloading (LV u...

Aug 21, 2020

Pulmonary endarterectomy (PEA) is a surgical procedure to remove old blood clots from pulmonary arteries in the lungs. In some cases, PEA leads to residual pulmonary hypertension (CTEPH), a progressiv...

Aug 20, 2020

Acute pulmonary embolism (PE) refers to a condition characterized by the blockage of a pulmonary artery, resulting in a blood clot in parts of the body. If not managed properly, acute PE is associated...