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Cardiology General

Effect of low vs. high haemoglobin transfusion trigger on cardiac output in patients undergoing elective vascular surgery: post-hoc analysis of a randomised trial.

Nov 05, 2020

During vascular surgery, restricted red-cell transfusion reduces frontal lobe oxygen (ScO ) saturation as determined by near-infrared spectroscopy. We evaluated whether inadequate increase in cardiac ...

Mechanical Thrombectomy using Distal Access Catheters: Current Status and Future Prospects.

Nov 05, 2020

Mechanical Thrombectomy (MT) using modern devices has proved to be efficacious in re-establishing intracranial circulation and reduced procedural times. We outline a number of endovascular techniques ...

Susceptibility Vessel Sign in Deep Perforating Arteries in Patients with Recent Small Subcortical Infarcts.

Nov 05, 2020

Recent small subcortical infarcts (RSSI) are considered an acute manifestation of cerebral small vessel disease. Paramagnetic signals in perforating arteries supplying RSSI may be detected on T2*-rela...

Rates of Vascular Events in Patients With Migraine: A MarketScan Database Retrospective Cohort Study.

Nov 05, 2020

To estimate the baseline rates of vascular events among people with migraine.Several novel medications that target the calcitonin gene-related peptide (CGRP) pathway are approved to treat people with ...

Osteoglycin silencing exerts inhibitory effects on myocardial fibrosis and epithelial/endothelial-mesenchymal transformation in a mouse model of myocarditis.

Nov 05, 2020

Osteoglycin (Ogn), a class III SLRP member with multiple glycosylation sites, has been proposed to be engaged in cardiac dysfunction and adverse remodeling in human heart failure following myocardial ...

Validation of the DAPT score in large-scale consecutive and contemporary patients population in the real world.

Nov 05, 2020

Dual antiplatelet therapy (DAPT) score emerged as a tool for quantification of ischemia and bleeding risks. However, there was discrepancy of the prediction ability of DAPT score in previous studies. ...

Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular K1.1 channel stimulators.

Nov 05, 2020

Quercetin represents one of the most studied dietary flavonoids; it exerts a panel of pharmacological activities particularly on the cardiovascular system. Stimulation of vascular K1.1 channels contri...

The impact of the Covid-19 pandemic on maternity services: A review of maternal and neonatal outcomes before, during and after the pandemic.

Nov 05, 2020

To explore any apparent trends in maternal or neonatal outcomes during the Covid-19 pandemic by comparing the maternity outcomes before, during and after the pandemic.A retrospective review was perfor...

Need for vitreous surgeries in proliferative diabetic retinopathy in 10 years follow-up: India Retinal Disease Study (IRDS) group Report no.2.

Nov 05, 2020

To report the 10 - year rate of vitrectomies and the associated factors in people with proliferative diabetic retinopathy (PDR) from a multicentric cohort of people with diabetes mellitus.Ten centres ...

The Circadian Clock, Shift Work, and Tissue-Specific Insulin Resistance.

Nov 05, 2020

Obesity and type 2 diabetes (T2D) have become a global health concern. The prevalence of obesity and T2D is significantly higher in shift workers compared to people working regular hours. An accepted ...

Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers.

Nov 05, 2020

Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNAs characterized by a covalently closed-loop structure generated through a special type of alternative splicing termed back-splici...

Investigating the genetic characteristics of CAD: Is there a role for myocardial perfusion imaging techniques?

Nov 05, 2020

Several environmental and genetic factors have been found to influence the development and progression of coronary artery disease (CAD). Although the effects of the environmental hazards on CAD pathop...

Outcomes and Long-term Mortality after Basilar Artery Occlusion A Cohort with up to 20-Year Follow-Up.

Nov 05, 2020

The data on long-term outcome after basilar artery occlusion (BAO) are scarce. Only a little is known about BAO survivors´ outcome over decades.We set out to investigate long-term survival and causes...

Exercise training in the treatment of paroxysmal atrial fibrillation: study protocol of the Cologne ExAfib Trial.

Nov 05, 2020

Atrial fibrillation (AF) is the most common form of cardiac arrhythmia and is associated with a number of comorbidities such as coronary artery disease and heart failure. While physical activity is al...

Simulations of blood pressure and identification of atrial fibrillation and arterial stiffness using an extended Kalman filter with oscillometric pulsation measurements.

Nov 05, 2020

The accuracy of systolic and diastolic blood pressure levels from oscillometric devices is difficult to assess for patients with atrial fibrillation and arterial stiffness; in such cases, changes in t...

Clinical characteristics and prognosis of myocardial infarction with non-obstructive coronary arteries (MINOCA): A prospective single-center study.

Nov 05, 2020

A definition of myocardial infarction with non-obstructive coronary arteries (MINOCA) was published by European Society of Cardiology in 2016. The aim of this study is to analyze the clinical profile ...

Fibrinogen Levels and Cognitive Profile Differences in Patients with Mild Cognitive Impairment.

Nov 05, 2020

Fibrinogen is considered a marker of vascular pathology, indicating a weakened blood-brain barrier, and has a causative role in neuroinflammation and neurodegeneration. Little is known about the relat...

Long-term safety of tofacitinib up to 9.5 years: a comprehensive integrated analysis of the rheumatoid arthritis clinical development programme.

Nov 02, 2020

Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). We report the largest integrated safety analysis of tofacitinib, as of March 2017, using data from p...

Genetic association study of fatal pulmonary embolism.

Nov 02, 2020

Pulmonary embolism (PE) is a complex multi-factorial disease and represents one manifestation of venous thromboembolism (VTE). Most commonly PE constitutes a complication of VTE's other clinical prese...

Cerebrovascular complications and vasculopathy in patients with herpes simplex virus central nervous system infection.

Nov 02, 2020

Herpes simplex viruses (HSV) are neurotropic and known to cause central nervous system (CNS) infections. We aimed to describe the clinical and imaging features of cerebrovascular complications in pati...