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Cardiology General

Genetic Determinants of PWD & Relation to AF

Dec 14, 2020

The P-wave duration (PWD) is an electrocardiographic measurement that represents atrial conduction. Prolonged or shortened PWD is associated with atrial fibrillation (AF). Exome-chip data was utilized...

GlycA for long-term outcome in T2DM secondary prevention.

Dec 14, 2020

Glycosylated acetyls (GlycA), a systemic marker of inflammation, were associated both with incident type 2 diabetes mellitus (T2DM) and incident cardiovascular (CV) disease. This study evaluates the p...

Heart failure in people with type 2 diabetes vs. those without diabetes: A retrospective observational study from South India.

Dec 14, 2020

Despite diabetes being an independent risk for HF, only some DM patients develop HF and hence our aim was to compare the clinical features of DM with and without HF and non-DM with and without HF.A re...

Low-density lipoprotein aggregation predicts adverse cardiovascular events in peripheral artery disease.

Dec 14, 2020

Peripheral artery disease (PAD) is a systemic manifestation of atherosclerosis that is associated with a high risk of major adverse cardiovascular events (MACE). LDL aggregation contributes to atheros...

Translational applications of computational modelling for patients with cardiac arrhythmias.

Dec 14, 2020

Cardiac arrhythmia is associated with high morbidity, and its underlying mechanisms are poorly understood. Computational modelling and simulation approaches have the potential to improve standard-of-c...

SETAP: epidemiology and prevention of stroke and transient ischaemic attack in Czech patients with atrial fibrillation.

Dec 14, 2020

The aim of this study is to analyse the prevalence, epidemiology, and anticoagulation prevention of stroke or transient ischaemic attack (TIA) in Czech patients with atrial fibrillation (AF).Retrospec...

Objective Risk Assessment vs Standard Care for Acute Coronary Syndromes: A Randomized Clinical Trial.

Dec 14, 2020

Although international guidelines recommend use of the Global Registries of Acute Coronary Events (GRACE) risk score (GRS) to guide acute coronary syndrome (ACS) treatment decisions, the prospective u...

LVEF’s Impact on Outcomes Post Ablation of AF in HF

Dec 14, 2020

Data obtained recently demonstrates favourable effects on left ventricular ejection fraction (LVEF) and left ventricular dysfunction improvement following ablation for atrial fibrillation (AF) in pati...

PV Isolation with Single Pulse IRE

Dec 13, 2020

Irreversible electroporation (IRE) is an upcoming nonthermal ablation technology used for atrial fibrillation (AF) patients for performing pulmonary vein (PV) isolation. The data obtained previously s...

Prioritizing Candidates of Post HF using Plasma Proteomics

Dec 13, 2020

Heart failure (HF) is the most widespread chronic complication of acute myocardial infarction (MI). This study aimed to understand the plasma proteins associated with post-MI HF and their gene express...

Risk Predictors of Appropriate ICD Therapy

Dec 13, 2020

The approaches at present fail to distinguish patients at low versus high risk for ventricular arrhythmias due to overreliance on left ventricular ejection fraction measure. In this study, statistical...

Association of Habitual Physical Activity with CVD Risk

Dec 13, 2020

A sedentary lifestyle is associated with increased risk for cardiovascular disease (CVD). Smartwatches enable accurate daily activity monitoring for physical activity measurement and intervention. Few...

Single‐Cell Transcriptomics of Cardiac Tissues from hiPSC‐CMs

Dec 11, 2020

To understand the intrinsic cardiac developmental and functional abnormalities in pulmonary atresia with the intact ventricular septum (PAIVS) free from effects secondary to anatomic defects, we perfo...

Automated Recognition of Regional Wall Motion Abnormalities

Dec 11, 2020

Automated interpretation of echocardiography by deep neural networks could support clinical reporting and improve efficiency. Whereas previous studies have evaluated spatial relationships using still ...

No Evidence for EMP-Derived Vascular Endothelial Cells

Dec 11, 2020

Endothelial cells are thought to newly emerge from the mesoderm to form the entire circulatory system. Lately, erythro-myeloid progenitors (EMPs) have been proposed to be a remarkable developmental or...

TLR5 Activation by Gut Microbiota Induces Apo-A1 in Liver

Dec 11, 2020

Dysbiosis of gut microbiota plays an essential role in cardiovascular diseases, but the molecular mechanisms are complex. An association between the gut microbiome and the variance in HDL-C (high-dens...

Endothelial Cell-Derived Factors Promote Pericyte Recruitment

Dec 11, 2020

In this study, the EC-derived factors that advance pericyte recruitment around endothelial cells and tube maturation were identified. Moreover, it was determined that the five primary endothelial cell...

Dapagliflozin’s Effect on Worsening of Patients with HF

Dec 11, 2020

In the DAPA-HF trial, dapagliflozin was added to guideline-recommended therapies, reducing the risk of mortality and heart failure (HF) hospitalization. In this study, the significance and frequency o...

Strategies for Transportation of Suspected Stroke Patients

Dec 11, 2020

Ischemic stroke patients non-LVO (large vessel occlusion) patients would require rapid IV thrombolysis in the nearest center. Whereas patients having LVO benefit from direct transportation for endovas...

Mast Cell Promotes Intracranial Aneurysm Rupture

Dec 11, 2020

Inflammation has emerged as a vital component of the pathophysiology of intracranial aneurysms. Mast cells have been identified previously in human intracranial aneurysm tissues, and their presence wa...