Dec 29, 2020

Tamoxifen prevents the recurrence of breast cancer and is also beneficial against bone demineralization and arterial diseases. Here, we tested whether tamoxifen can accelerate endothelial healing and ...

Dec 29, 2020

Cardiac pacemaker cells (PCs) in the sinoatrial node (SAN) have a distinct gene expression program that initiates the heartbeat. Although critical SAN transcription factors, including Isl1 (Islet-1), ...

Dec 29, 2020

Studies done previously on the relationship between arterial stiffness and diabetes were primarily cross-sectional. A few longitudinal studies focused on one single direction. Whether the association ...

Dec 29, 2020

Mortality is significantly increased following a hospitalization for decompensated heart failure (HF), during which diuretics are observed to be intensified. It remains indefinite how risk is affected...

Dec 28, 2020

The current electrocardiographic algorithms lack sensitivity to diagnose acute myocardial infarction (AMI) in the presence of the left bundle branch block. This retrospective, multicenter cohort study...

Dec 28, 2020

Endothelial cells (ECs) are highly glycolytic and generate most of their energy via the breakdown of glucose to lactate. The primary role of ECs is to allow the transport of glucose to its surrounding...

Dec 28, 2020

The elderly experience profound systemic responses after stroke, contributing to higher mortality and more severe long-term disability. Recent studies have revealed that the composition of the gut mic...

Dec 28, 2020

Doxorubicin is considered to be one of the most powerful antitumor agents available in the market. However, its clinical use is restricted as it poses severe cardiotoxicity risk. Research done prior t...

Dec 28, 2020

Infection occurs commonly in patients with acute ischemic stroke (AIS). This study aimed to investigate the association of infection with long- and short-term risk of recurrent stroke in patients with...

Dec 28, 2020

Improving the door-to-needle times (DNTs) for thrombolysis in acute ischemic stroke (AIS) patients improves outcomes. However, participation in DNT improvement initiatives have only been limited to ac...

Dec 28, 2020

Expert guidelines are yet to specify an upper age limit for alteplase for thrombolysis of acute ischemic stroke (AIS). The European regulatory criteria constricted its use to patients aged from 18-80 ...

Dec 28, 2020

The remodeling of the extracellular matrix plays a vital role in cardiovascular diseases (CVDs). Utilising a mouse model of postnatal ascending aortic aneurysms, it has been reported that abnormal mec...

Dec 28, 2020

The pathophysiology of hypertension remains incompletely understood. The associations of circulating metabolites with longitudinal blood pressure (BP) changes were investigated in the Prospective Inve...

Dec 25, 2020

Illicit drug use—including use of stimulants like methamphetamine, amphetamines, and cocaine—continues to be a growing problem throughout the United States. Research has shown that the misuse of i...

Dec 24, 2020

Pulmonary hypertension (PH) results in increased right ventricular (RV) afterload and ventricular remodeling. Sacubitril/valsartan (sac/val) is a dual-acting drug composed of the neprilysin inhibitor ...

Dec 24, 2020

Exosomes are small extracellular vesicles that function as intercellular messengers and effectors. Exosomal cargo contains small regulatory molecules, including miRNAs, mRNAs, lncRNAs, and small pepti...

Dec 24, 2020

Regression of atherosclerosis is an important clinical goal; however, the pathways that mediate atherosclerotic inflammation and reversal of plaques are poorly understood. Regulatory T cells (Tregs) a...

Dec 24, 2020

Mitral valve prolapse (MVP) is one of the most common valvular disorders. Aldosterone (Aldo) promotes fibrosis in the myocardium, and MR (mineralocorticoid receptor) antagonists (MRAs) improve cardiac...

Dec 24, 2020

Hypoxia promotes renal damage and the progression of chronic kidney disease (CKD). However, nothing is known about erythrocyte S1P in CKD. This study aimed to investigate the function and metabolic ba...

Dec 24, 2020

Lung cancer is the leading cause of death from cancer in Japan. Studies in other countries have reported a venous thromboembolism (VTE) rate of 4%-20% in cancer patients. In this study, we aimed to de...