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Cardiology General

Efecto de las estatinas en el desarrollo de síndrome postrombótico: estudio de cohorte.

Dec 31, 2020

Explorar la asociación entre consumo de estatinas (CE) y desarrollo de síndrome postrombótico (SPT).Cohorte retrospectiva con pacientes con primer episodio de trombosis venosa profunda (TVP) entre ...

Clinical impact of bifurcation angle change between diastole and systole in complex stenting for left main distal bifurcation: The Milan and New-Tokyo (MITO) Registry.

Dec 31, 2020

We assessed the impact of pre-percutaneous coronary intervention (PCI) bifurcation angle change (BAC) on clinical outcomes.There are little available data about the impact of BAC in unprotected left m...

The Role of Cardiac Testing with the 0/1-Hour High-Sensitivity Cardiac Troponin Algorithm Evaluating for Acute Myocardial Infarction.

Dec 31, 2020

The role of cardiac testing in the 3 zones (rule-out, observation, and rule-in) of the 0/1-hour algorithm to evaluate for acute myocardial infarction (AMI) has not been well-studied. This study evalua...

Regional anesthesia is underutilized for carotid endarterectomy despite improved perioperative outcomes compared to general anesthesia.

Dec 31, 2020

The choice of anesthetic for carotid endarterectomy (CEA) continues to be controversial. Recent literature suggests improved outcomes with the use of regional anesthesia (RA) compared to general (GA)....

Clinical Utility of the Logarithmically Transformed Ratio of Triglycerides-to- High-Density Lipoprotein Cholesterol and Its Relationship with Other Atherosclerosis-Related Lipid Factors in Type 2 Diabetes.

Dec 31, 2020

Elevated triglyceride (TG) levels and reduced high-density lipoprotein-cholesterol (HDL-c) levels indicate lipid abnormalities, but their levels alone do not reflect the actual status of plasma ather...

Bach1 Plays an Important Role in Angiogenesis Through Regulation of Oxidative Stress.

Dec 31, 2020

Bach1 is a known transcriptional repressor of the heme oxygenase-1 (HO-1) gene. The purpose of this study was to determine whether angiogenesis is accelerated by genetic ablation of Bach1 in a mouse i...

Automated coronary artery tree segmentation in coronary CTA using a multiobjective clustering and toroidal model-guided tracking method.

Dec 31, 2020

Accurate coronary artery tree segmentation can now be developed to assist radiologists in detecting coronary artery disease. In clinical medicine, the noise, low contrast, and uneven intensity of medi...

Antithrombotic management of patients with acute coronary syndrome and atrial fibrillation undergoing coronary stenting: a prospective, observational, nationwide study.

Dec 31, 2020

The aim of the study was to assess current management of patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) undergoing coronary stenting.Non-interventional, prospective, nationwi...

Mouse Model for Studying Hemostatic Function of Human Platelets

Dec 29, 2020

Platelets are essential to the pathogenesis of atherothrombosis and the formation of a hemostatic plug. The preclinical animal models, mice in particular, provide a major platform to evaluate the safe...

Quantification of Vasodepression & Cardioinhibition during T-VVS

Dec 29, 2020

Evaluating the relative contributions of vasodepression and cardioinhibition to the blood pressure (BP) decrease in tilt-induced vasovagal syncope (T-VVS) requires methods that reflect BP physiology a...

Association of ID & Estrogen with Ischemic Stroke

Dec 29, 2020

An association is determined between the use of oral contraceptives (CC) in iron deficiency patients (ID) and Ischemic stroke (IS). However, it is still unclear as to the underlying mechanisms. With t...

Cardiac Macrophages’ Self-Maintenance Prevents DiCM

Dec 29, 2020

Doxorubicin-induced cardiomyopathy (DiCM) is a primary cause of heart failure and mortality in cancer patients, in which macrophage-orchestrated inflammation serves as an essential pathological mechan...

Critical Role of Neprilysin in Kidney Angiotensin Metabolism

Dec 29, 2020

Kidney homeostasis is critically determined by the coordinated activity of the renin-angiotensin system (RAS), including the balanced synthesis of its main effector peptides Ang (angiotensin) II and A...

Effects of Epeleuton on NAFLD & Cardiometabolic Markers

Dec 29, 2020

Epeleuton is a 15‐hydroxy eicosapentaenoic acid ethyl ester, a second‐generation synthetic n‐3 fatty acid derivative of eicosapentaenoic acid. The primary objective was to assess the effect of e...

Effects of Fatty Acid & Strong Statin Therapy on Coronary Plaques

Dec 29, 2020

Vascular healing response associated with adjunctive n‐3 polyunsaturated fatty acid therapy in patients receiving strong statin therapy remains unclear. This study aimed to evaluate the effect of po...

Epigenomes Reveal Genetic Variants Relevant for Cardiac Disease

Dec 29, 2020

Identifying genetic markers for heterogeneous complex diseases such as heart failure is challenging and requires prohibitively large cohort sizes in genome-wide association studies to meet the stringe...

Somatic Gain of KRAS Function Causes Vascular Malformations

Dec 29, 2020

We previously identified somatic activating mutations in the KRAS (Kirsten rat sarcoma viral oncogene homologue) gene in the endothelium of the majority of human sporadic brain arteriovenous malformat...

B55α/PP2A Limits EC Apoptosis During Vascular Remodeling

Dec 29, 2020

How endothelial cells (ECs) migrate and form an immature vascular plexus has been extensively studied. However, mechanisms underlying vascular remodeling remain poorly established. A better understand...

Transcriptional Patterning of the VCS System

Dec 29, 2020

The heartbeat is organized by the cardiac conduction system (CCS), a specialized network of cardiomyocytes. Patterning of the CCS into atrial node versus ventricular conduction system (VCS) components...

Genome-Wide Analysis Identifies Human TBX3 Pacemaker

Dec 29, 2020

The development and function of the pacemaker cardiomyocytes of the sinoatrial node (SAN), the leading pacemaker of the heart, are tightly controlled by a conserved network of transcription factors, i...