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Diabetes

Higher Risk of Urinary Tract Infections in Renal Transplant Recipients Receiving Pentamidine Versus Trimethoprim-Sulfamethoxazole (TMP-SMX) for Pneumocystis Pneumonia Prophylaxis.

Aug 20, 2020

Urinary tract infection (UTI) is one of the most common infectious complications among renal transplant patients. Trimethoprim-sulfamethoxazole (TMP-SMX) is routinely used as first-line prophylaxis ag...

Liver steatosis is highly prevalent and is associated with metabolic risk factors and liver fibrosis in adult patients with type 1 Gaucher disease.

Aug 20, 2020

Gaucher disease (GD) is associated with peculiar metabolic abnormalities (i.e. hypermetabolic state, peripheral insulin resistance, dyslipidemia), partially reverted by enzyme replacement therapy (ERT...

Health-related quality of life 90 days after stroke assessed by the International Consortium for Health Outcome Measurement (ICHOM) standard set.

Aug 20, 2020

Stroke has detrimental effects in multiple health domains not captured by routine scales. The International Consortium for Health Outcome Measurement has developed a standardized set for self-reported...

Complement 3 mediates periodontal destruction in patients with type 2 diabetes by regulating macrophage polarization in periodontal tissues.

Aug 17, 2020

Diabetes aggravates the risk and severity of periodontitis, but the specific mechanism remains confused. Complement 3 (C3) is closely related to complications of type 2 diabetes (T2DM). In the present...

[Clinical application of nose ring drain in severe diabetic foot infection].

Aug 17, 2020

To evaluate the effectiveness of the nose ring drain (NRD) in treatment of severe diabetic foot infection.The clinical data of 35 patients with severe diabetic foot infection who were treated with NRD...

[Effectiveness of lower extremity Dellon triple nerve decompression in treatment of early-stage diabetic Charcot foot].

Aug 17, 2020

To study the effectivenss of lower extremity Dellon triple nerve decompression in the treatment of early-stage diabetic Charcot foot.The clinical data of 24 patients with Eichenholtz stage 0-1 diabeti...

Chronic Conditions, Visual Impairment, & Healthcare Use: Examining Key Patterns

Aug 13, 2020

The number of older adults in the United States living with multimorbidity—defined as the co-occurrence of at least 2 chronic conditions—has increased rapidly over the past few decades. “Visual ...

Nf1 Heterozygous Mice Recapitulate the Anthropometric and Metabolic Features of Human Neurofibromatosis Type 1.

Aug 13, 2020

Neurofibromatosis type 1 (NF1) is a heritable cancer predisposition syndrome resulting from mutations in the NF1 tumor suppressor gene. Genotype-phenotype correlations for NF1 are rare due to the larg...

Glucose 6-phosphate dehydrogenase inhibition sensitizes melanoma cells to metformin treatment.

Aug 13, 2020

Most cancer cells exacerbate the pentose phosphate pathway (PPP) to enhance biosynthetic precursors and antioxidant defenses. Metformin, which is used as a first-line oral drug for the treatment of ty...

The effect of a computerized best practice alert system in an outpatient setting on metabolic monitoring in patients on second-generation antipsychotics.

Aug 10, 2020

Metabolic syndrome is a well-documented adverse effect of second-generation antipsychotics (SGAs). Patients with metabolic syndrome are at an increased risk of potentially fatal cardiovascular events,...

High prevalence of elevated serum liver enzymes in Chinese children suggests metabolic syndrome as a common risk factor.

Aug 10, 2020

This study investigated the pattern of liver enzymes in a large cohort of Chinese children and adolescents, including 16 383 individuals aged 4-18 years old recruited at six medical centres in Chi...

Use of real-world data to emulate a clinical trial and support regulatory decision-making: assessing the impact of temporality, comparator choice and methods of adjustment.

Aug 10, 2020

External controls have been primarily used in the setting of single-arm trials of rare diseases; their use in common diseases has not been readily investigated, nor is there guidance on how to best se...

AHA/HFSA Statement on Diabetes & Heart Failure

Aug 09, 2020

With emerging data suggesting that therapies for type 2 diabetes mellitus (T2DM) can impact outcomes among patients with heart failure (HF), and vice versa, but no single document that comprehensively...

Model free sliding mode controller for blood glucose control: Towards artificial pancreas without need to mathematical model of the system.

Aug 06, 2020

The mechanism of glucose regulation in human blood is a nonlinear complicated biological system with uncertain parameters and external disturbances which cannot be imitated accurately by a simple math...

Associations between sarcopenia and white matter alterations in older adults with diabetes mellitus: A diffusion tensor imaging study.

Aug 06, 2020

Older adults with diabetes mellitus are susceptible to sarcopenia. Diffusion tensor imaging (DTI) studies have also indicated that patients with diabetes have altered white matter integrity. However, ...

Association between Oral Lichen Planus and Systemic Conditions and Medications: Case-Control Study.

Aug 06, 2020

The aim of this study is to investigate the association between oral lichen planus (OLP) and a variety of systemic conditions, medication, and supplement usage.156 patients diagnosed with OLP and 156 ...

Dietary fiber intake and risk of type 2 diabetes in a general Japanese population: the Hisayama Study.

Aug 03, 2020

The investigation of the influence of the dietary fiber intake on the incidence of type 2 diabetes in a general Japanese population.A total of 1,892 subjects aged 40-79 years without diabetes at basel...

Metabolic syndrome in type 1 diabetes and its association with diabetes complications.

Aug 03, 2020

To assess the prevalence of metabolic syndrome in type 1 diabetes, and its age-related association with diabetes complications.Australian National Diabetes Information Audit and Benchmarking (ANDIAB) ...

Prevalence of Latent and Overt Polyautoimmunity in Autoimmune Thyroid Disease: A Systematic Review and Meta-analysis.

Aug 03, 2020

Thyroid autoimmunity is the most frequent condition involved in polyautoimmunity (PolyA). However, the frequency of latent and overt PolyA in patients with autoimmune thyroid disease (AITD) as the ind...

ACA Medicaid Expansion Associated With Increased Medicaid Participation and Improved Health Among Near-Elderly: Evidence From the Health and Retirement Study.

Jul 30, 2020

The Affordable Care Act (ACA) dramatically expanded health insurance, but questions remain regarding its effects on health. We focus on older adults for whom health insurance has greater potential to ...