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Diabetes

Effects of a One-week Vacation with Various Activity Programs on Metabolism and Adipokines.

Dec 03, 2020

This study was conducted as part of a larger study of East Tyrolean health tourism, and investigates the effects of an active seven-day vacation on metabolic parameters and adipokines. Fifty-two healt...

Microvascular Benefits of New Antidiabetic Agents: A Systematic Review and Network Meta-Analysis of Kidney Outcomes.

Nov 30, 2020

Diabetic kidney disease affects nearly one-third of US adults with prevalent type 2 diabetes mellitus. The use of new antidiabetic medications in the prevention and treatment of diabetic kidney diseas...

Insulin resistance is central to long-term reversal of histologic non-alcoholic steatohepatitis after metabolic surgery.

Nov 30, 2020

Non-alcoholic steatohepatitis(NASH)is considered as the hepatic counterpart of the metabolic syndrome.To investigate the determinants of NASH reversal in patients undergoing biliopancreatic diversion(...

Do GLP-1 receptor agonists increase the risk of breast cancer? A systematic review and meta-analysis.

Nov 30, 2020

Risk of cancer is a major concern in the development of drugs for the treatment of obesity and diabetes. In randomized controlled trials (RCTs) of the liraglutide development program, a glucagon-like ...

[Vida saludable perdida por discapacidad aguda, crónica y muerte prematura en hipertensión arterial].

Nov 26, 2020

Objetivo: Determinar la vida saludable perdida por hipertensión arterial sin diabetes mellitus. Método: La vida saludable perdida se determinó a partir de la discapacidad crónica (enfermedad renal...

Increased risk of ischemic heart disease and diabetes in inflammatory bowel disease.

Nov 26, 2020

 Previous studies showed inconsistent results regarding associations between inflammatory bowel disease (IBD) and risk of ischemic heart disease (IHD) and diabetes. The present study aimed to make a...

Berberine promotes peri-implant osteogenesis in diabetic rats by ROS-mediated IRS-1 pathway.

Nov 26, 2020

Accompanying with diabetes mellitus-induced osteoporosis (DM-OS), diabetic patients show poor peri-implant osteogenesis after implantation for dentition defect. Berberine (BBR), a candidate oral hypog...

The effect of cinnamon supplementation on lipid profiles in patients with type 2 diabetes: A systematic review and meta-analysis of clinical trials.

Nov 23, 2020

The present systematic review and meta-analysis was performed to evaluate the effect of cinnamon supplementation on blood lipid profiles in patients with type 2 diabetes.A systematic search (with no l...

Sugar-containing beverages and their association with risk of breast, endometrial, ovarian and colorectal cancers among Canadian women.

Nov 23, 2020

The association of sugar containing beverages (SCBs) with risk of breast, endometrial, ovarian and colorectal cancers is unclear. Therefore, we investigated these associations in the Canadian Study of...

Whole-body vibration promotes lipid mobilization in hypothalamic obesity rat.

Nov 19, 2020

This study aimed to analyze the effect of whole-body vibration (WBV) on metabolic parameters using the monosodium l-glutamate (MSG) model of obesity.MSG-obese rats that were exposed to WBV on a vibrat...

Glycemic traits and Alzheimer's disease: a mendelian randomization study.

Nov 19, 2020

Previous observational studies have reported an association between impaired glucose metabolism and Alzheimer's disease. This study aimed to examine the causal association of glycemic traits with Alzh...

First-Phase Insulin and Amylin after Bariatric Surgery: A Prospective Randomized Trial on Patients with Insulin Resistance or Diabetes after Gastric Bypass or Sleeve Gastrectomy.

Nov 19, 2020

Most patients with severe obesity show glucose intolerance. Early after sleeve gastrectomy (LSG) or gastric bypass (LRYGB), a marked amelioration in glycemic control occurs. The underlying mechanism i...

High glucose load and endotoxemia among overweight and obese Arab women with and without diabetes: An observational study.

Nov 16, 2020

Dietary intake influences gut microbiota activity. Nevertheless, there is a lack of evidence available that illustrates the acute effects of high glucose meal on metabolic endotoxemia. The present stu...

Population pharmacokinetics and dosing optimization of metformin in Chinese patients with type 2 diabetes mellitus.

Nov 16, 2020

Approximately 35% of patients fail to attain ideal initial blood glucose control under metformin monotherapy. The objective of this observational study is to simulate the optimal protocol of metformin...

The Impact of Obesity on Risk Factors for Adverse Outcomes in Patients Undergoing Elective Posterior Lumbar Spine Fusion.

Nov 16, 2020

Retrospective case control study.To determine the influence of obesity on risk factors for adverse outcome after lumbar spine fusion (LSF).Obesity is risk factor for complications after LSF and poses ...

Characterization of local gut microbiome and intestinal transcriptome responses to rosiglitazone treatment in diabetic db/db mice.

Nov 12, 2020

The gut microbiota has been implicated in the therapeutic effects of antidiabetics. It is unclear if antidiabetics directly influences gut microbiome-host interaction. Oral peroxisome proliferator-act...

Characteristics and Comparison of 32 COVID-19 and Non-COVID-19 Ischemic Strokes and Historical Stroke Patients.

Nov 12, 2020

The presence of COVID-19 infection may increase the risk of thrombotic events including ischemic strokes. Whilst a number of recent reports suggest that COVID-19 associated stroke tends to be severe, ...

The DPP4 inhibitor linagliptin ameliorates renal injury and accelerated resolution in a rat model of crescentic nephritis.

Nov 12, 2020

Dipeptidyl peptidase 4 (DPP4) inhibitors are a class of oral glucose lowering drugs, used in the treatment of type 2 diabetes. In a pilot study using human kidney biopsies we observed high DPP4 expres...

Photobiomodulation reduces hepatic lipogenesis and enhances insulin sensitivity through activation of CaMKKβ/AMPK signaling pathway.

Nov 09, 2020

Photobiomodulation (PBM) could improve systemic blood glucose and insulin resistance in diet-induced diabetic mice. A few possible molecular mechanisms for the beneficial effects of PBM on diabetes ha...

Associations of urinary concentrations of phthalate metabolites, bisphenol A, and parabens with obesity and diabetes mellitus in a Korean adult population: Korean National Environmental Health Survey (KoNEHS) 2015-2017.

Nov 09, 2020

Phthalates and bisphenol A (BPA) have been suspected as risk factors for obesity and diabetes mellitus (DM) among humans. However, associations between phthalates and environmental phenols are often i...