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Dementia

Bilingualism Is Associated with a Delayed Onset of Dementia

Feb 10, 2020

Some studies have linked bilingualism with a later onset of dementia, Alzheimer's disease (AD), and mild cognitive impairment (MCI). Not all studies have observed such relationships, however. Differen...

Rostral intralaminar thalamic deep brain stimulation ameliorates memory deficits and dendritic regression in β-amyloid-infused rats.

Feb 10, 2020

Rostral intralaminar thalamic deep brain stimulation (ILN-DBS) has been shown to enhance attention and cognition through neuronal activation and brain plasticity. We examined whether rostral ILN-DBS c...

Why Not a Global Postural Reeducation as an Alternative Therapy Applied to Alzheimer's Patients in Nursing Homes? A Pioneer Randomized Controlled Trial.

Feb 04, 2020

The classical gymnastics has always given great importance to exercises of -rachis extension and abduction of the arms during deep inhalation to acquire a greater -thoracic capacity.The aim of this st...

Different response to instrumental tests in relation to cognitive demand after dopaminergic stimulation in previously treated patients with Parkinson's disease.

Feb 04, 2020

Instrumental measurement of response assets and movement behaviour gained importance as addition to rating procedures to determine the efficacy of therapeutic interventions in patients with Parkinson'...

Methylene Blue Protects Against Sevoflurane-Induced Cognitive Dysfunction by Suppressing Drp1 deSUMOylation in Aged Mice.

Feb 04, 2020

Exposure to sevoflurane and other inhalational anesthetics can induce cognitive impairment in elderly patients. Studies have indicated that methylene blue (MB) has beneficial effects on multiple neuro...

Amyloid Fibril-Induced Astrocytic Glutamate Transporter Disruption Contributes to Complement C1q-Mediated Microglial Pruning of Glutamatergic Synapses.

Feb 04, 2020

The complement C1q plays a critical role in microglial phagocytosis of glutamatergic synapses and in the pathogenesis of neuroinflammation in Alzheimer's disease (AD). We recently reported that upregu...

Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ.

Jan 31, 2020

This study aims to investigate whether magnolol (MG), a natural neolignane compound, can prevent AD induced by beta-amyloid (Aβ) and the possible mechanisms involved. MG dose-dependently reduces Aβ ...

Metformin and trimetazidine ameliorate diabetes-induced cognitive impediment in status epileptic rats.

Jan 31, 2020

Patients with diabetes and epilepsy are more prone to cognitive impairment, dementia, and even Alzheimer's disease. Diabetes-induced inflammatory process is one of the main contributing factors; howev...

Characterization of the dynamic behavior of neural activity in Alzheimer's disease: exploring the non-stationarity and recurrence structure of EEG resting-state activity.

Jan 31, 2020

Mild cognitive impairment (MCI) and dementia due to Alzheimer's disease (AD) have been shown to induce perturbations to normal neuronal behavior and disrupt neuronal networks. Recent work suggests tha...

Efficacy and Safety of Psychostimulants for Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Jan 31, 2020

Several reports of the effectiveness of the use of psychostimulants for the treatment of Alzheimer's disease (AD) are available.A systematic review and meta-analysis was conducted including double-bli...

Ambivert degree identifies crucial brain functional hubs and improves detection of Alzheimer's Disease and Autism Spectrum Disorder.

Jan 31, 2020

Functional modules in the human brain support its drive for specialization whereas brain hubs act as focal points for information integration. Brain hubs are brain regions that have a large number of ...

Pharmaceutical intervention after evaluation of the risk of ictus in elderly patients institutionalized with atrial fibrillation.

Jan 30, 2020

To evaluate the risk of having a stroke and the risk of bleeding in institutionalized patients with atrial fibrillation. Atrial fibrillation is a common cardiac arrhythmia associated with increased mo...

Neovascular age-related macular degeneration and its association with Alzheimer's disease.

Jan 30, 2020

In developed countries, people of advanced age go permanently blind most often due to age-related macular degeneration, while at global level, this disease is the third major cause of blindness, after...

Negative Evidence for a Role of APH1B T27I Variant in Alzheimer's Disease.

Jan 30, 2020

γ-secretase is a macromolecular complex that catalyzes intramembranous hydrolysis of over 100 membrane-bound substrates. The complex is composed of presenilin (PS1 or PS2), anterior pharynx defect-1(...

Prediction of Freezing of Gait in Patients with Parkinson's Disease by Identifying Impaired Gait Patterns.

Jan 30, 2020

Freezing of gait (FoG) prediction, combined with rhythmic laser cues, may help Parkinson's disease (PD) patients overcome FoG episodes. This study aimed to utilize the impaired gait patterns preceding...

Impact of posttranslational modifications on atomistic structure of fibrinogen.

Jan 30, 2020

Oxidative stress in humans is related to various pathophysiological processes, which can manifest in numerous diseases including cancer, cardiovascular diseases, and Alzheimer's disease. On the atomis...

A survey on machine and statistical learning for longitudinal analysis of neuroimaging data in Alzheimer's disease.

Jan 30, 2020

Recently, longitudinal studies of Alzheimer's disease have gathered a substantial amount of neuroimaging data. New methods are needed to successfully leverage and distill meaningful information on the...

[Facts and figures of clinical pathways in Italy: results from the PDTA Net project.]

Jan 24, 2020

The approval of clinical pathways (CPWs) represents a key step to focus the care management on the patient. The PDTA Net project, by ReS Foundation and CINECA, aims to create a reference tool to study...

Drug ntervention after evaluation of the risk of ictus in elderly patients w Afib

Jan 24, 2020

To evaluate the risk of having a stroke and the risk of bleeding in institutionalized patients with atrial fibrillation. Atrial fibrillation is a common cardiac arrhythmia associated with increased mo...

Calculating Risk for Poor Outcomes After Transcatheter Aortic Valve Replacement.

Jan 24, 2020

To outline the tools available to help understand the risk of transcatheter aortic valve replacement (TAVR) and the gaps in knowledge regarding TAVR risk estimation.Review of the literature.Two models...

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