Author: Rebecca Shover

People with difficult-to-treat rheumatoid arthritis who do not have success with one JAK inhibitor could succeed either by cycling to other JAK inhibitors or switching to a biologic. Both strategies led to comparable control of...

Tigulixostat was successfully tested in patients with gout and hyperuricemia for its serum urate-lowering capacity. The drug was overall well tolerated and without particular safety signals. These results support dose finding...

A retrospective chart review analysis in the first 24 hours after hospital admission revealed four predictors that discriminate between children with multisystem inflammatory syndrome and other syndromes: hypotension, abdominal...

Patients with rheumatoid arthritis and associated interstitial lung disease could be safely treated with pirfenidone, the TRAIL1 study showed. In participants receiving the antifibrotic, lung function decline was slowed down,...

While high rates of mortality are recognized, data regarding recurrent ischemic events and rehospitalization for heart failure (HF) among patients with HF and acute coronary syndrome (ACS) are limited. Researchers evaluated the...

Approximately 40% of clinically diagnosed patients with heterozygous familial hypercholesterolemia (HeFH) have pathogenic variants of other lipid-related genes in addition to those of conventional FH genes, according to a study....

The normal delay in age of onset of atherosclerotic cardiovascular disease (ASCVD) in women versus men may be shortened in individuals with familial hypercholesterolemia (FH), according to a study. Researchers found that both...

The likelihood of developing retinopathy on hydroxychloroquine medication is markedly increased by several independent risk factors, including long-term use and high-dose regimens. Also, the presence of chronic kidney disease...

New data on the advantages and disadvantages of statins for patients with rheumatoid arthritis showed significant reductions in cardiovascular and all-cause mortality but an increased risk for type 2 diabetes mellitus. Not all...

Several autoimmune or inflammatory rheumatic diseases are associated with an increased risk for experiencing a breakthrough COVID-19 infection, despite complete vaccination. The risk varies according to the type of diagnosis and...

A multi-ethnic cohort study demonstrates that 29% of patients with lupus had an inadequate response to the COVID-19 vaccines. Interestingly, patients taking anti-malarials showed an almost 12-times improved response. Overall...

The Moderna mRNA 1273 SARS-CoV-2 vaccine is safe in immunosuppressed adults with autoimmune disease and not associated with severe disease flares. However, therapy with mycophenolate mofetil and rituximab is associated with a...

Cardiovascular guidelines advise statin therapy for adults aged 20-75 with low-density lipoprotein cholesterol (LDL-C) of 190 mg/dL or greater with a goal of lowering LDL-C by 50% or more. Furthermore, early-life accumulation of...

Previous research has shown that race and economic status negatively impact children’s heart transplant (HT) outcomes. To determine the effect of race on access to left ventricular assist devices (LVAD) and survival...

Twice-yearly dosing with inclisiran (after the initial and 3-month doses) provided effective and sustained lipid lowering in patients, irrespective of their baseline BMI, and was generally well tolerated, according to a study....

To assess the relationship between sustained maximal inspiratory pressure (SMIP) and maximal inspiratory pressure (MIP) and a number of physiologic and functional parameters in patients with heart failure (HF), 50 male veterans...

Researchers studied the relationship between depressiveness as measured by the Patient-Health-Questionnaire-9 (PHQ-9) and factors related to heart rate variability (HRV) from 24h-Holter ECG recording in the MyoVasc study. HRV...