Author: Janine Anthes

Nature communications 2018 07 189(1) 2794 doi 10.1038/s41467-018-05273-7 Abstract Mutations in proteins like FUS which cause Amyotrophic Lateral Sclerosis (ALS) result in the aberrant formation of stress granules while...

Nature biotechnology 2018 07 16() doi 10.1038/nbt.4192 Abstract CRISPR-Cas9 is poised to become the gene editing tool of choice in clinical contexts. Thus far, exploration of Cas9-induced genetic alterations has been limited to...

Nature 2018 07 18() doi 10.1038/s41586-018-0324-7 Abstract In DNA repair, the resection of double-strand breaks dictates the choice between homology-directed repair-which requires a 3′ overhang-and classical non-homologous...

Cancer immunology research 2018 07 20() pii 10.1158/2326-6066.CIR-17-0405 Abstract The success of chimeric antigen receptor (CAR)-mediated immunotherapy in acute lymphoblastic leukemia (ALL) highlights the potential of T-cell...

Nature 2018 07 18() doi 10.1038/s41586-018-0353-2 Abstract Thermogenesis by brown and beige adipose tissue, which requires activation by external stimuli, can counter metabolic disease. Thermogenic respiration is initiated by...

Cellular and molecular gastroenterology and hepatology 2018 04 126(2) 133-148 doi 10.1016/j.jcmgh.2018.04.003 Abstract Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis....

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018 07 19() JCO2017776112 doi 10.1200/JCO.2017.77.6112 Abstract Purpose CPX-351 is a dual-drug liposomal encapsulation of cytarabine...

Nature communications 2018 07 209(1) 2845 doi 10.1038/s41467-018-05049-z Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share key features, including accumulation of the RNA-binding protein...

Nature 559(7714) 336-338 doi 10.1038/d41586-018-05679-9 Abstract

Nature 2018 07 18() doi 10.1038/s41586-018-0342-5 Abstract Acute lymphoblastic leukaemia (ALL) has a marked propensity to metastasize to the central nervous system (CNS). In contrast to brain metastases from solid tumours,...

Science translational medicine 10(450) pii 10.1126/scitranslmed.aar3342 Abstract Combination anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) and anti-programmed cell death protein 1 (PD-1) therapy promotes antitumor immunity and...

Nature methods 2018 07 16() doi 10.1038/s41592-018-0048-5 Abstract The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its...