- Physician's Weekly

A Comparison of Smoking History in the Electronic Health Record With Self-Report.

Jan 27, 2020

Knowing patients’ smoking history helps guide who may benefit from preventive services such...

Charcot-Leyden Crystal Protein/Galectin-10 Interacts with Cationic Ribonucleases and is Required for Eosinophil Granulogenesis.

Jan 27, 2020

The human eosinophil Charcot-Leyden Crystal (CLC) protein is a member of the Galectin superfamily...

Intratracheal injection of nitric oxide, generated from air by pulsed electrical discharge, for the treatment of pulmonary hypertension in awake ambulatory lambs.

Jan 27, 2020

To test the feasibility, safety, and efficacy of intratracheal delivery of nitric oxide (NO)...

Effects of miR-34b/miR-892a Upregulation and Inhibition of ABCB1/ABCB4 on Melatonin-Induced Apoptosis in VCR-Resistant Oral Cancer Cells.

Jan 27, 2020

Multidrug resistance (MDR) is the resistance of cells toward various drugs commonly used in tumor...

Semiparametric regression and risk prediction with competing risks data under missing cause of failure.

Jan 27, 2020

The cause of failure in cohort studies that involve competing risks is frequently incompletely...

Assessing the Clinical Utility of Point of Care HbA1c in the Ophthalmology Outpatient Setting.

Jan 24, 2020

Effective management of diabetic retinopathy requires multidisciplinary input. We aimed to evaluate the impact of point of care (POC) HbA1c testing as a tool to identify patients most in need of specialist diabetologist input...

Detection of active and inactive phases of thyroid-associated ophthalmopathy using deep convolutional neural network.

Jan 24, 2020

This study aimed to establish a deep learning system for detecting the active and inactive phases of thyroid-associated ophthalmopathy (TAO) using magnetic resonance imaging (MRI). This system could provide faster, more...

Current management of Inherited Retinal Degenerations (IRD) patients in Europe. Results of a multinational survey by the European Vision Institute Clinical Research Network EVICR.net.

Jan 24, 2020

An increasing number of gene therapies are developed for Inherited Retinal Degenerations (IRD). To date, one treatment has been approved for clinical use (FDA USA 2017, EMA Europe 2018, MoHAP UAE 2019, SFDA Saudi Arabia 2019,...

Analysis of the Refractive Profile of Children with Oculocutaneous Albinism versus an Age-Matched Non-Albino Group.

Jan 24, 2020

To find out and analyze the points of difference in the refractive profile between children with complete oculocutaneous albinism (OCA) and an age-matched, non-albino group seeking paediatric ophthalmic examination.A...

Association between different scale bars in dermoscopic images and diagnostic performance of a market-approved deep learning convolutional neural network for melanoma recognition.

Jan 24, 2020

Studies systematically unravelling possible causes for false diagnoses of deep learning convolutional neural networks (CNNs) are scarce, yet needed before broader application.The objective of the study was to investigate whether...

The impact of antibiotics on efficacy of immune checkpoint inhibitors in malignancies: A study based on 44 cohorts.

Jan 24, 2020

Pre-clinical and clinical data had revealed the gut microbiome plays a critical role in immune checkpoint inhibitors (ICIs) efficacy. This study was designed to investigate whether antibiotics (ATBs) affect the prognosis of...

Adherence to Primary Prevention and Skin Self-Examination Practices by Spanish Melanoma Patients.

Jan 24, 2020

The incidence of cutaneous melanoma, an important global public health problem, has been increasing over the last several decades.In order to decrease melanoma-related mortality, ways to communicate and implement the correct...

Response to systemic therapy in locally advanced and metastatic renal cell carcinoma: can it be predicted?

Jan 24, 2020

: Renal cell carcinoma is no longer considered a monolithic disease, but a group of different entities exhibiting unique molecular alterations requiring a tailored systemic therapy approach. One of the remaining challenges is...

The impact of antibiotics on efficacy of immune checkpoint inhibitors in malignancies: A study based on 44 cohorts.

Jan 24, 2020

Pre-clinical and clinical data had revealed the gut microbiome plays a critical role in immune checkpoint inhibitors (ICIs) efficacy. This study was designed to investigate whether antibiotics (ATBs) affect the prognosis of...

Otoferlin is a prognostic biomarker in patients with clear cell renal cell carcinoma: A systematic expression analysis.

Jan 24, 2020

To comprehensively investigate the role of otoferlin as a prognostic and diagnostic biomarker in clear cell renal cell carcinoma.Three independent cohorts were used to study otoferlin in clear cell renal cell carcinoma: The...

Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5α-dihydrotestosterone regulation.

Jan 24, 2020

Resistance to androgen-deprivation therapies and progression to so-called castrate-resistant prostate cancer (CRPC) remain challenges in prostate cancer (PCa) management and treatment. Among other alterations, CRPC has been...

Reconstructing tumor evolutionary histories and clone trees in polynomial-time with SubMARine.

Jan 24, 2020

Tumors contain multiple subpopulations of genetically distinct cancer cells. Reconstructing their evolutionary history can improve our understanding of how cancers develop and respond to treatment. Subclonal reconstruction...