Molecular Insights into Recurrent Spontaneous Abortion: Identification of Potential Biomarkers & Altered Genes
This study delves into the molecular mechanisms of long non-coding RNAs (lncRNAs) in recurrent...
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Adjusting Injectable Contraceptive Use for Months Since the Last Injection.
Injectables are one of the most popular methods of contraception worldwide, particularly in sub-Saharan Africa. An advantage of injectables over shorter-acting methods is that they provide additional flexibility by not requiring...
Read MoreProinsulin C-peptide inhibits high glucose-induced migration and invasion of ovarian cancer cells.
Proinsulin C-peptide, a biologically active polypeptide released from pancreatic β-cells, is known to prevent hyperglycemia-induced microvascular leakage; however, the role of C-peptide in migration and invasion of cancer cells...
Read MoreThe application and use of artificial intelligence in cancer nursing: A systematic review.
Artificial Intelligence is being applied in oncology to improve patient and service outcomes. Yet, there is a limited understanding of how these advanced computational techniques are employed in cancer nursing to inform clinical...
Read MoreReal-world treatment patterns and clinical outcomes in patients treated with eribulin after prior phosphoinositide 3-Kinase inhibitor treatment for metastatic breast cancer.
In 2010, the US Food and Drug Administration approved eribulin for the treatment of metastatic breast cancer (MBC). Since then, the treatment landscape has evolved with many new therapy classes, a more recent one being the small...
Read MoreExpression and clinical significance of hypoxia-induced long non-coding RNA TCONS_I2_00001955 in breast cancer.
Long non-coding RNAs (lncRNAs) have been found to play important roles in occurrence, development, and metastasis of various tumors. We aimed to screen long non-coding RNAs (lncRNAs) that promote invasion and metastasis of...
Read MoreAn Assessment of Business of Medicine Knowledge in Obstetrics and Gynecology Fellows: A Pilot Study.
To identify knowledge gaps in business education among obstetrics and gynecology fellows.An online anonymous survey was distributed to obstetrics and gynecology subspecialty fellows including pediatric and adolescent gynecology...
Read MoreThe Natural History of Insomnia: Evaluating illness severity from acute to chronic insomnia; Is the first the worst?
The 3P and 4P models represent illness severity over the course of insomnia disorder. The 3P model suggests that illness severity is worst during acute onset. The 4P model suggests that illness severity crescendos with...
Read MoreProfile of Acute Encephalitis Syndrome Patients from South India.
Encephalitis is a major public health problem worldwide that causes huge emotional and economic loss to humanity. Encephalitis, being a serious illness, affects people of all ages. The aim is to describe the sociodemographic,...
Read MoreA prospective study of drug-drug interaction between antiepileptic drugs and meropenem in patients in a tertiary hospital in China from January 2020 to March 2023.
This study aimed to determine the minimum interaction between different antiepileptic drugs (AEDs) and meropenem (MEPM) for clinical treatment.The data of 91 patients enrolled in the neurology department from January 2020 to...
Read MoreNovel Biomaterials Based Strategies for Neurodegeneration: Recent Advancements and Future Prospects.
Neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, pose significant challenges for effective treatment due to the complex nature of the central nervous...
Read MorePotential Therapeutic Approach Using Aromatic l-amino Acid Decarboxylase and Glial-derived Neurotrophic Factor Therapy Targeting Putamen in Parkinson’s Disease.
Parkinson’s disease (PD) is a neurodegenerative illness characterized by specific loss of dopaminergic neurons, resulting in impaired motor movement. Its prevalence is twice as compared to the previous 25 years and affects...
Read MoreThoracic Outlet Syndrome in the Pediatric and Young Adult Population.
This study aimed to assess both nonsurgical and operative treatment outcomes of pediatric and young adult patients with thoracic outlet syndrome (TOS) at a tertiary care pediatric hospital.A retrospective chart review of...
Read MoreTreatment Options for Tennis Elbow – An Umbrella Review.
The main goal of the present umbrella review was to provide the most up-to- date and evidence-based results regarding the various treatment options for tennis elbow (TE), which hopefully will significantly decrease the...
Read MorePreoperative Alcohol Use, Postoperative Pain, and Opioid Use After Coronary Artery Bypass Surgery.
Chronic alcohol use is associated with chronic pain and increased opioid consumption. The association between chronic alcohol use and acute postoperative pain has been studied minimally. The authors’ objective was to...
Read MoreImpact of harm minimization interventions on reducing blood-borne infection transmission and some injecting behaviors among people who inject drugs: an overview and evidence gap mapping.
This study aimed to synthetize the evidence on the effectiveness of harm minimization interventions on reducing blood-borne infection transmission and injecting behaviors among people who inject drugs (PWID) through a...
Read MoreImpact of Alcohol Consumption on Multiple Sclerosis Using Model-based Standardization and Misclassification Adjustment Via Probabilistic Bias Analysis.
The etiology of multiple sclerosis (MS) is still not well-demonstrated, and assessment of some risk factors like alcohol consumption has problems like confounding and measurement bias. To determine the causal effect of alcohol...
Read MoreSafety and Effectiveness of Cinnomer on Disease Characteristics, Depression, and Quality of Life of Patients with Multiple Sclerosis: A Phase IV, Post-marketing, Prospective, Multicenter Study.
Every patient diagnosed with definite multiple sclerosis (MS) should begin disease modifying therapies. Cinnomer contains 40 mg glatiramer acetate (GA) and is available in prefilled syringes and autoinjector devices.A phase IV...
Read MoreReal-world effectiveness of Anti-CGRP monoclonal antibodies compared to OnabotulinumtoxinA (RAMO) in chronic migraine: a retrospective, observational, multicenter, cohort study.
Chronic migraine (CM) is a disabling condition with high prevalence in the general population. Until the recent approval of monoclonal antibodies targeting the calcitonin gene-related peptide (Anti-CGRP mAbs), OnabotulinumtoxinA...
Read MoreCalcitonin gene-related peptide (CGRP) levels in peripheral blood in patients with idiopathic intracranial hypertension and migraine.
Calcitonin gene-related peptide (CGRP) plays a dominant role in migraine. This prospective study was designed to investigate CGRP levels in patients with idiopathic intracranial hypertension (IIH) and compare the results of...
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