For a study, researchers sought to determine if low-dose aspirin usage was related to an increased risk of having a small-for-gestational-age (SGA) neonate in a previous pregnancy among women who had a history of having an SGA neonate in a previous pregnancy. They conducted register-based cohort research on women in their second pregnancy with a history of having an SGA neonate (birth weight less than the 10th percentile). The relationship between low-dose aspirin usage in a future pregnancy and the delivery of an SGA neonate or a severely SGA neonate (birth weight less than the third percentile) was assessed using inverse propensity-weighted estimation, which accounted for possible confounders.
About 801 (9.5%) of the 8,416 women who had an SGA neonate during their first pregnancy used low-dose aspirin during their second pregnancy. The prevalence of SGA neonates was comparable in mothers who used low-dose aspirin (21.7%) and those who did not use aspirin (20.7%). Low-dose aspirin usage during pregnancy was not linked with an increased risk of having an SGA newborn (aRR 0.86, 95% CI 0.67–1.10) or a severely SGA neonate (aRR 0.98, 95% CI 0.71–1.34). They did subgroup analyses based on preeclampsia status because of the substantial connection between preeclampsia and SGA. Low-dose aspirin was not linked with an increased risk of having an SGA (aRR 0.83, 95% CI 0.63–1.10) or severely SGA (aRR 1.02, 95% CI 0.73–1.44) newborn in women who had an SGA neonate and co-existing preeclampsia in their first pregnancy. Furthermore, no link was seen among women who got preeclampsia during their second pregnancy.
Low-dose aspirin was not related to a lower chance of having an SGA or severely SGA newborn in a second pregnancy among women who had previously had an SGA neonate. According to the data, low-dose aspirin should not be utilized to prevent recurrent SGA.
Reference:journals.lww.com/greenjournal/Fulltext/2022/04000/Low_Dose_Aspirin_for_Preventing_Birth_of_a.8.aspx
