For a study, it was determined that antineutrophil cytoplasmic antibody-associated small-vessel vasculitis, several investigations found indicators of relapse. However, the function of smoking as a relapse risk factor was yet to be determined. As a result, researchers wanted to see if smoking history is a dose-dependent independent risk factor for recurrence of antineutrophil cytoplasmic antibody-associated small-vessel vasculitis. A total of 122 patients with granulomatosis with polyangiitis and microscopic polyangiitis (MPA) from 9 nephrology clinics were included in this multicenter retrospective cohort research. Multivariate Cox proportional hazards models with clinically relevant covariates were used to investigate the dose-response associations between cigarette smoking and outcomes. The period from remission to the first recurrence was the primary outcome.
During the study’s 41-month observation period (median; interquartile range, 23–66 months), 118 (95.8%) and 34 (21.7%) patients, respectively, had at least one remission and recurrence. Smoking was shown to be substantially linked with relapse (P=0.003) in a log-rank test. Current smoking was linked to relapse in multivariate Cox proportional hazards models (adjusted hazard ratio, 7.48; 95% CI; 2.73–21.0). There was also a link between the probability of relapse and the number of pack-years smoked (P=0.004). Smoking, on the other hand, was not linked to remission.
Relapse of MPA was linked to smoking, which was a substantial and dose-dependent risk factor. Smoking cessation should be urged for all MPA patients.
Reference:journals.lww.com/jclinrheum/Abstract/2018/10000/Smoking_Is_a_Risk_Factor_for_Relapse_of.3.aspx
