Background There is increasing evidence that opioids interfere with the oral bioavailability of P2Y inhibitors leading to delayed onset of antiplatelet effects. Several strategies have been proposed to mitigate this interaction including utilizing alternative analgesic agents in the management of ischemic chest pain. Methods The lidocAine Versus Opioids In MyocarDial Infarction (AVOID-2) study is a phase II, pre-hospital, open-label, non-inferiority, randomized controlled trial conducted by Ambulance Victoria and Monash University in metropolitan Melbourne, Victoria, Australia. The purpose of the study is to compare the analgesic effect (reduction in pain by arrival to hospital) and safety (e.g. adverse drug reactions) (co-primary endpoints) of intravenous lidocaine versus intravenous fentanyl in 300 adult patients attended by ambulance with suspected ST-elevation myocardial infarction (STEMI). Secondary endpoints and a cardiac magnetic resonance imaging (MRI) sub-study will also compare infarct size between these two groups. Conclusions The evaluation of alternative analgesic agents in the management of acute coronary syndromes is urgently needed to manage the opioid-P2Y inhibitor interaction. The results of this trial will have significant implications on the emergency management of acute coronary syndromes internationally.Copyright © 2018. Published by Elsevier Inc.
About The Expert
Himawan Fernando
Catherine Milne
Ziad Nehme
Jocasta Ball
Stephen Bernard
Michael Stephenson
Paul S Myles
Janet E Bray
Jeffrey Lefkovits
Danny Liew
Karlheinz Peter
Angela Brennan
Diem Dinh
Emily Andrew
Andrew J Taylor
Karen Smith
Dion Stub
References
PubMed