A new assessment method for right ventricular diastolic function using right heart catheterization by pressure-volume loop.

Jul 03, 2023

Experts: Yoshitaka Isotani,Eisuke Amiya,Masaru Hatano,Hiroyuki Kiriyama,Masae Uehara,Junichi Ishida,Masaki Tsuji,Chie Bujo,Koichi Narita,Satoshi Ishii,Nobutaka Kakuda,Shun Minatsuki,Hiroki Yagi,Akihito Saito,Genri Numata,Takanobu Yamada,Takahiro Kurihara,Tatsuya Suzuki,Issei Komuro

Diastolic stiffness coefficient (β) and end-diastolic elastance (Eed) are ventricular-specific diastolic parameters. However, the diastolic function of right ventricle had not been investigated sufficiently due to the lack of established evaluation method. We evaluated the validity of these parameters calculated using only data of right heart catheterization (RHC) and assessed it in patients with restrictive cardiomyopathy (RCM) and cardiac amyloidosis. We retrospectively analyzed 46 patients with heart failure who underwent RHC within 10 days of cardiac magnetic resonance (CMR). Right ventricular end-diastolic volume and end-systolic volume were calculated using only RHC data, which were found to be finely correlated with those obtained from CMR. β and Eed calculated by this method were also significantly correlated with those derived from conventional method using CMR. By this method, β and Eed were significantly higher in RCM with amyloidosis group than dilated cardiomyopathy group. In addition, the β and Eed calculated by our method were finely correlated with E/A ratio on echocardiography. We established an easy method to estimate β and Eed of right ventricle from only RHC. The method finely demonstrated right ventricular diastolic dysfunction in patients with RCM and amyloidosis.
© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

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ABOUT THE EXPERTS

Yoshitaka Isotani,Eisuke Amiya,Masaru Hatano,Hiroyuki Kiriyama,Masae Uehara,Junichi Ishida,Masaki Tsuji,Chie Bujo,Koichi Narita,Satoshi Ishii,Nobutaka Kakuda,Shun Minatsuki,Hiroki Yagi,Akihito Saito,Genri Numata,Takanobu Yamada,Takahiro Kurihara,Tatsuya Suzuki,Issei Komuro

Yoshitaka Isotani

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Eisuke Amiya

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Masaru Hatano

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Department of Advanced Medical Center for Heart Failure, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Hiroyuki Kiriyama

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Masae Uehara

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Junichi Ishida

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Masaki Tsuji

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Chie Bujo

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Koichi Narita

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Satoshi Ishii

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Nobutaka Kakuda

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Shun Minatsuki

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Hiroki Yagi

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Akihito Saito

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Genri Numata

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Takanobu Yamada

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Takahiro Kurihara

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Tatsuya Suzuki

Electrical Engineering Program, Graduate School of Science and Technology, Meiji University, Kawasaki, Japan.

Issei Komuro

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.