A deep learning system for detecting diabetic retinopathy across the disease spectrum.

May 31, 2021

Contributor: Ling Dai,Liang Wu,Huating Li,Chun Cai,Qiang Wu,Hongyu Kong,Ruhan Liu,Xiangning Wang,Xuhong Hou,Yuexing Liu,Xiaoxue Long,Yang Wen,Lina Lu,Yaxin Shen,Yan Chen,Dinggang Shen,Xiaokang Yang,Haidong Zou,Bin Sheng,Weiping Jia

A deep learning system for detecting diabetic retinopathy across the disease spectrum.

Retinal screening contributes to early detection of diabetic retinopathy and timely treatment. To facilitate the screening process, we develop a deep learning system, named DeepDR, that can detect early-to-late stages of diabetic retinopathy. DeepDR is trained for real-time image quality assessment, lesion detection and grading using 466,247 fundus images from 121,342 patients with diabetes. Evaluation is performed on a local dataset with 200,136 fundus images from 52,004 patients and three external datasets with a total of 209,322 images. The area under the receiver operating characteristic curves for detecting microaneurysms, cotton-wool spots, hard exudates and hemorrhages are 0.901, 0.941, 0.954 and 0.967, respectively. The grading of diabetic retinopathy as mild, moderate, severe and proliferative achieves area under the curves of 0.943, 0.955, 0.960 and 0.972, respectively. In external validations, the area under the curves for grading range from 0.916 to 0.970, which further supports the system is efficient for diabetic retinopathy grading.

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About The Expert

Ling Dai

Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, 200233, China.

MoE Key Lab of Artificial Intelligence, Artificial Intelligence Institute, Shanghai Jiao Tong University, Shanghai, 200240, China.

Liang Wu

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, 200233, China.

Huating Li

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, 200233, China.

Chun Cai

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, 200233, China.

Qiang Wu

Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China.

Hongyu Kong

Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China.

Ruhan Liu

Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.

MoE Key Lab of Artificial Intelligence, Artificial Intelligence Institute, Shanghai Jiao Tong University, Shanghai, 200240, China.

Xiangning Wang

Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China.

Xuhong Hou

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, 200233, China.

Yuexing Liu

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, 200233, China.

Xiaoxue Long

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, 200233, China.

Yang Wen

Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.

MoE Key Lab of Artificial Intelligence, Artificial Intelligence Institute, Shanghai Jiao Tong University, Shanghai, 200240, China.

Lina Lu

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai Eye Diseases Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200040, China.

Yaxin Shen

Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.

MoE Key Lab of Artificial Intelligence, Artificial Intelligence Institute, Shanghai Jiao Tong University, Shanghai, 200240, China.

Yan Chen

Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China.

Dinggang Shen

School of Biomedical Engineering, Shanghai Tech University, Shanghai, China.

Shanghai United Imaging Intelligence Co., Ltd., Shanghai, China.

Xiaokang Yang

Shanghai Institute for Advanced Communication and Data Science, Shanghai Key Laboratory of Digital Media Processing and Transmission, Shanghai Jiao Tong University, Shanghai, 200240, China.

Haidong Zou

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai Eye Diseases Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200040, China. zouhaidong@sjtu.edu.cn.

Bin Sheng

Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. shengbin@cs.sjtu.edu.cn.

MoE Key Lab of Artificial Intelligence, Artificial Intelligence Institute, Shanghai Jiao Tong University, Shanghai, 200240, China. shengbin@cs.sjtu.edu.cn.

Weiping Jia

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, 200233, China. wpjia@sjtu.edu.cn.

References

PubMed