Photo Credit: ttsz

The following is a summary of “LV function recovery and outcomes in Takotsubo syndrome,” published in the September 2024 issue of Cardiology by Almendro-Delia et al.

Researchers started a retrospective study to identify predictors and assess the prognostic impact of the time taken for left ventricular (LV) recovery following Takotsubo syndrome (TTS).

They reviewed prospective serial imaging data from the nationwide RETAKO registry to assess LV recovery timing. Factors linked to late (>10 days) vs. early (<10 days) recovery were analyzed using multivariable logistic regression. Cox models compared long-term mortality between groups, with recovery time as a continuous variable.

The results showed that of 1,463 patients (median age 73, 13% men), 373 (25%) had late LV recovery, while 1,090 (75%) had early recovery. Older age, neurological disorders, coronary artery disease, cancer, physical triggers, high inflammatory markers, cardiogenic shock, and lower LVEF at admission predicted late recovery. After 4 years, the death risk was higher in patients with late recovery (16.0% vs. 8.6%; aHR 1.31, CI: 1.12-1.60), increasing by 8% for every additional 10-day delay in LV recovery (aHR 1.08, CI: 1.04-1.13). 

Investigators concluded that late LV recovery after TTS is linked to lower short- and long-term survival. Patients without early recovery may benefit from closer clinical monitoring to improve outcomes.

Source: acc.org/Latest-in-Cardiology/Journal-Scans/2024/09/20/14/55/recovery-of-left-ventricular