1. A randomized controlled trial by Lin and colleagues compared artificial intelligence (AI) to standard care in triaging suspected cases of myocardial infarction.
2. AI-assisted triaging of patients based on ECG interpretations significantly decreased the door-to-balloon and ECG-to-balloon times for patients.
Evidence Rating Level: 1 (Excellent)
Study Rundown: Timely intervention via primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) is crucial for patient prognosis. However, it is challenging to distinguish between STEMI patients and those with undifferentiated chest pain in acute clinical settings. Lin and colleagues conducted a randomized controlled trial to compare the triage performance of artificial intelligence (AI)-assisted electrocardiogram (ECG) analysis against the standard care protocol. 43,234 patients were assigned randomly to an intervention group and a control group. The intervention group used an AI algorithm to analyze 12-lead ECG waveform data in real time, which alerted cardiologists of suspected STEMI cases. The control group utilized patient assessment by frontline physicians, who can then refer patients to cardiology. The primary endpoints were the door-to-balloon time and ECG-to-balloon time in STEMI patients. The study found that both primary endpoints were significantly shorter for the intervention group compared to the control group. However, there were no significant differences between their prognostic indicators (ejection fraction, highest level of high-sensitivity cardiac troponin I and creatinine kinase, length of hospitalization). Overall, this study demonstrated AI’s ability to improve the timeliness of care delivery for STEMI patients.
Click here to read the study in NEJM AI
Relevant Reading: Current and Future Use of Artificial Intelligence in Electrocardiography
In-Depth [randomized controlled trial]: 43,234 adult patients without prior coronary angiography who received an ECG in the emergency or inpatient department were randomized to the intervention or control group in a 1:1 ratio. The AI algorithm used in this trial reported a positive predictive value of 93.2% in a preliminary study. The cardiologists were not blinded to their group assignment. Instead of AI, frontline physicians in the control group had a Philips automatic ECG analysis system to assist with interpretation. The primary endpoints were the door-to-balloon time and ECG-to-balloon time in STEMI patients. The former was a known prognostic indicator, and the latter was more relevant for evaluating inpatient cases. In the emergency department, the median door-to-balloon time was 82.0 minutes in the intervention group, compared to 96.0 minutes in the control group (p = 0.002). For both emergency and inpatient cases, the median ECG-to-ballon time was 78.0 minutes (intervention) versus 83.6 minutes (control) (p = 0.011). Furthermore, post hoc analysis was conducted for hospitalization prognostic indicators for STEMI: ejection fraction, the highest level of high-sensitivity cardiac troponin I and creatinine kinase, and length of hospitalization. There were no significant differences in these measures between the two groups. The authors concluded that AI-ECG analysis demonstrated its potential to enhance the timeliness of STEMI treatments, and further research with longer follow-up periods is required to clarify the intervention’s clinical benefits.
Image: PD
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