Causal association between sleep traits and autoimmune arthritis: Evidence from a bidirectional Mendelian randomization study.

Jan 22, 2024

Experts: Yajia Li,Qiangxiang Li,Ziqin Cao,Jianhuang Wu

To explore whether there is a genetic causal relationship between sleep traits and the risk of autoimmune arthritis (AA).
Univariable and multivariable Mendelian randomization was employed using genome-wide association studies data to assess sleep traits’ associations with AAs, including rheumatoid arthritis (RA), ankylosing spondylitis, and psoriatic arthritis. The inverse-variance weighted method served as the primary analysis, supplemented by the CAUSE method to improve power and mitigate false positives. Mediation Mendelian randomization was used to quantify direct and indirect effects.
Significant associations were shown between insomnia symptoms and increased risk of overall RA (odds ratio = 2.75, 95% confidence interval 1.45-5.22) and seronegative RA (odds ratio = 6.95, 95% confidence interval 2.47-19.56). CAUSE results revealed an association of insomnia symptoms with overall RA and seronegative RA, as well as the sleep duration with overall RA. After the adjustment for body mass index, alcohol status, smoking status, and physical activity levels, multivariable analyses revealed that genetic predisposition to insomnia symptoms and prolonged sleep duration showed independent negative associations with the risk of overall RA and seropositive RA. In the reversed multivariable analyses, a borderline negative association was shown in the overall RA-sleep duration and a positive association of seropositive RA with the risk of insomnia symptoms.
This study demonstrated a potential bidirectional causal relationship that genetic predisposition to insomnia symptoms and shorter sleep duration was associated with the risk of AA, especially RA. Genetic predisposition to RA was also associated with decreased sleep duration, as well as increased insomnia symptom risk.

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Author

admin

View all posts

ABOUT THE EXPERTS

Yajia Li,Qiangxiang Li,Ziqin Cao,Jianhuang Wu

Yajia Li

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Qiangxiang Li

National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Ningxia Geriatric Disease Clinical Research Center, People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia Hui Autonomous Region, China; Hunan Provincial People’s Hospital, Department of Hunan Institute of Geriatrics, Changsha, Hunan, China.

Ziqin Cao

National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: xyeyyziqincao@csu.edu.cn.

Jianhuang Wu

National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: wujianhuang11@csu.edu.cn.