With an increasing number of chronic diseases and related disabilities, modern medicine is falling short of offering definitive, cost-effective, long-term solutions. As we realize contemporary medicine’s limitations and side effects, we are gravitating towards whole-person care. Taking learnings from integrative medicine treatment of musculoskeletal pains, I comprehended that a paradigm shift is needed in thinking about etiopathogenesis and diagnosing disease. Different healing possibilities can be identified in humans if we shift our focus from reductionist science to whole-person care. Each health condition is an outcome of disturbed homeostasis involving multiple body systems. Based on homeostatic balancing principles and clinical experience, five interrelated and interdependent pathways are discussed. Based on these pathways, a working model of integrative medicine is presented. It can act as a template for medical practitioners to start integrative medicine practice for the benefit of patients. To make integrative medicine mainstream, there is a need to standardize care, frame regulations, train and educate the practitioners. At the same, it shall be put to rigorous scientific experimentation, research, and scrutiny.Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.