To analyze the vascular density values (VD) in the superficial and the deep retinal network and in all perimacular sectors of diabetic eyes without clinical retinopathy, comparing them to that of healthy, nondiabetic control eyes. We investigated the factors that may influence these values.
This was a cross-sectional study including diabetics without diabetic retinopathy and healthy control subjects. All subjects underwent OCTA examination (RTVue-XR Avanti; Optovue, Fremont, CA, USA). The scanned area was 3×3mm and centered on the fovea. In the superficial and deep capillary plexus, we evaluated the total VD, parafoveal, temporal, nasal, superior and inferior sectors, as well as the superior and inferior hemi-sector VD. The sectors with the greatest area under the curve (AUC) were determined. We evaluated the correlation between certain risk factors and VD values.
VD values in all sectors of the superficial capillary plexus layer and deep capillary plexus layer in the diabetic group were significantly lower than in the control group. Among all the parameters, the superficial total VD and superficial parafoveal VD had the greatest AUC (0.992 and 0.991 respectively). The sector with the greatest AUC was the temporal sector in both the SCP (0.990) and DCP (0.976). Age, creatinine clearance and hyperlipemia correlated with vascular density.
Superficial and deep retinal VD are both decreased in diabetic patients without diabetic retinopathy. Our results suggest that OCTA might be a promising tool for diabetic retinopathy screening. Quantitative microvascular changes might precede clinical damage.

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