Comparing Rates of Change in Moderate to Advanced Glaucoma: Retinal Nerve Fiber Layer vs. Bruch’s Membrane Opening-Minimum Rim Width.

May 08, 2023

Experts: Lynn Shi,Massood Mohammadi,Vahid Mohammadzadeh,Erica Su,Robert E Weiss,Joseph Caprioli,Kouros Nouri-Mahdavi

To compare rates of change (RoC) of peripapillary retinal nerve fiber layer (RNFL) and Bruch’s membrane opening-based minimum rim width (BMO-MRW) thickness in moderate-to- advanced glaucoma DESIGN: Prospective cohort study.
Longitudinal optical coherence tomography (OCT) optic nerve head volume scans of 113 eyes of 113 glaucoma patients with moderate-to-advanced or central damage were exported. We estimated and compared global and sectoral RoC with linear mixed effects models (LMM) and simple linear regression (SLR) of RNFL and BMO-MRW thickness. Permutation analyses were used to test significance of RoC in the SLR model. We also compared longitudinal signal-to-noise ratios (LSNR) defined as RoC divided by residual SD between the two groups.
Mean (SD) follow-up and median (IQR) OCT scan sessions were 5.2 (1.3) years and 10 (8-11), respectively. Baseline average (SD) visual field mean deviation was -9.2 (5.8) dB. Based on SLR, a higher proportion of significant negative RNFL RoC was observed compared to BMO-MRW in the inferotemporal (35% vs. 20%; p=0.015) and inferonasal (42% vs. 17%; p<0.001) sectors. Permutation analyses also demonstrated a higher proportion of worsening RNFL RoC than BMO-MRW in the inferotemporal (p=0.026) and inferonasal (p<0.001) sectors along with overall lower positive RoC. LSNR for RNFL was significantly more negative than that of BMO-MRW globally, and in the inferotemporal, inferonasal, and superonasal sectors (p≤0.01).
Longitudinal RNFL OCT measurements are more likely to detect structural change and demonstrate higher SNR compared to BMO-MRW in eyes with central or moderate to advanced glaucoma damage at baseline.

Copyright © 2023. Published by Elsevier Inc.

Author

admin

View all posts

ABOUT THE EXPERTS

Lynn Shi,Massood Mohammadi,Vahid Mohammadzadeh,Erica Su,Robert E Weiss,Joseph Caprioli,Kouros Nouri-Mahdavi

Lynn Shi

Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.

Massood Mohammadi

Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.

Vahid Mohammadzadeh

Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.

Erica Su

Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California.

Robert E Weiss

Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California.

Joseph Caprioli

Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.

Kouros Nouri-Mahdavi

Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. Electronic address: nouri-mahdavi@jsei.ucla.edu.