Evaluation of Dry Eye Severity and Ocular Surface Inflammation in Patients with Pemphigus and Pemphigoid.

Jan 16, 2023

Experts: Jianing Feng,Yingyi Liu,Yuerong Ren,Wen Shi,Huanmin Kang,Yixin Tan,Ruifang Wu,Guiying Zhang,Yan He

To evaluate ocular surface involvement, tear cytokine levels, and histopathological changes in pemphigus and pemphigoid patients.
A total of 22 patients (15 pemphigus and 7 pemphigoids) and 21 non-diseased controls were enrolled in our study. All participants underwent ocular surface evaluation, which included ocular surface disease index test, slit lamp observation, dry eye-related examination, tear multicytokine analysis, and conjunctival impression cytology.
Pemphigus and pemphigoid patients presented much more severe conjunctivochalasis, corneal epithelial defects, corneal opacity, symblepharon and dry eye. Severe ocular surface squamous metaplasia and a significant increase of tear macrophage inflammatory protein-1beta, tumor necrosis factor-alpha, interleukin (IL)-1β, IL -6, and IL-8 occurred in pemphigus and pemphigoid patients.
Our results revealed that ocular surface inflammation and dry eye persist in most pemphigus and pemphigoid patients, and do not occur in parallel with the systemic course. Regular ophthalmological examinations and local anti-inflammatory should be provided for pemphigus and pemphigoid patients.

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ABOUT THE EXPERTS

Jianing Feng,Yingyi Liu,Yuerong Ren,Wen Shi,Huanmin Kang,Yixin Tan,Ruifang Wu,Guiying Zhang,Yan He

Jianing Feng

Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Ophthalmology, Hunan Clinical Research Center of Ophthalmic Disease, Changsha, Hunan, China.

Xi’an People’s Hospital (Xi’an Fourth Hospital), Shaanxi Eye Hospital, Northwest University Affiliated People’s Hospital, Xi’an, Shaanxi Province, China.

Yingyi Liu

Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Ophthalmology, Hunan Clinical Research Center of Ophthalmic Disease, Changsha, Hunan, China.

Yuerong Ren

Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Ophthalmology, Hunan Clinical Research Center of Ophthalmic Disease, Changsha, Hunan, China.

Wen Shi

Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Ophthalmology, Hunan Clinical Research Center of Ophthalmic Disease, Changsha, Hunan, China.

Huanmin Kang

Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Ophthalmology, Hunan Clinical Research Center of Ophthalmic Disease, Changsha, Hunan, China.

Yixin Tan

Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Ruifang Wu

Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Guiying Zhang

Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Yan He

Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Ophthalmology, Hunan Clinical Research Center of Ophthalmic Disease, Changsha, Hunan, China.