Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination may fail to sufficiently protect transplant recipients against coronavirus disease 2019 (COVID-19). We retrospectively evaluated COVID-19 in kidney transplant recipients (n=226) after BNT162b2 mRNA vaccine administration. The control group consisted of unvaccinated patients (n=194) during the previous pandemic wave. We measured anti-spike protein immunoglobulin G (IgG) levels and cellular responses, using enzyme-linked immunosorbent spot assay, in a prospective cohort after vaccination (n=31) and recovery from COVID-19 (n=19). COVID-19 was diagnosed in 37 (16%) vaccinated and 43 (22%) unvaccinated patients. COVID-19 severity was similar in both groups, with patients exhibiting a comparable need for hospitalization (41% vs. 40%, P=1.000) and mortality (14% vs. 9%, P=0.726). Short post-transplantation periods were associated with COVID-19 after vaccination (P<0.001). Only 5 (16%) patients achieved positive SARS-CoV-2 IgG after vaccination, and 17 (89%, P<0.001) recovered from COVID-19 (median IgG levels, 0.6 vs. 52.5 AU/mL, P<0.001). A cellular response following vaccination was present in the majority (n=22, 71%), with an increase in interleukin 2 secreting T cells (P<0.001). Despite detectable T-cell immunity after mRNA vaccination, kidney transplant recipients remained at a high risk of severe COVID-19. Humoral responses induced by vaccination were significantly lower than that after COVID-19.
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