A host-coupling bio-nanogenerator for electrically stimulated osteogenesis.

Jul 8, 2021

Contributor: Bin Yu,Zhiguang Qiao,Jinjie Cui,Meifei Lian,Yu Han,Xing Zhang,Weiqi Wang,Xingge Yu,Hao Yu,Xudong Wang,Kaili Lin

Implantable self-powered generators (ISPGs) have been extensively explored as energy supplies for driving electronics and electrically stimulated therapeutics in vivo. However, some drawbacks arise, such as complicated architectonics, inescapability of wire connection, energy instability, and consumption. In this study, a host-coupling bio-nanogenerator (HCBG) is developed to configure a self-powered regional electrical environment for powerful bone regeneration. An HCBG consists of a porous electret nanofiber mat coupled with interstitial fluid and stimulated objects of the host after implantation, forming a host coupling effect. This bio-nanogenerator not only overcomes the disadvantages of general ISPGs, but also accomplishes both biomechanical energy scavenging and electrical stimulation therapeutics. The enhancement of osteogenesis differentiation of bone marrow mesenchymal stem cells in vitro and bone regeneration in vivo are remarkably achieved. Moreover, osteogenic ability is systematically evaluated by regulating the electrical performance of HCBGs. Osteogenic differentiation is activated by upregulating more cytosolic calcium ion, following to activate the calcium ion-induced osteogenic signal pathway, while applying electrical stimulation. As an implantable medical technology, the HCBG provides an explorative insight to facilitate the development of ISPG-based electrical medical therapeutics.
Copyright © 2021. Published by Elsevier Ltd.

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About The Expert

Bin Yu

Department of Oral & Cranio-Maxillofacial Surgery, National Clinical Research Centre for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Zhiguang Qiao

Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China; Clinical and Translational Research Centre for 3D Printing Technology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Jinjie Cui

Department of Oral & Cranio-Maxillofacial Surgery, National Clinical Research Centre for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Meifei Lian

Clinical and Translational Research Centre for 3D Printing Technology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Yu Han

Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China; Clinical and Translational Research Centre for 3D Printing Technology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Xing Zhang

State Key Laboratory of Mechanical Systems and Vibration, Shanghai Jiao Tong University, Shanghai, 200240, China.

Weiqi Wang

Department of Oral & Cranio-Maxillofacial Surgery, National Clinical Research Centre for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Xingge Yu

Department of Oral & Cranio-Maxillofacial Surgery, National Clinical Research Centre for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Hao Yu

State Key Lab for Modification of Chemical Fibers & Polymer Materials, College of Material Science & Engineering, Donghua University, Shanghai, 201620, China. Electronic address: yh@dhu.edu.cn.

Xudong Wang

Department of Oral & Cranio-Maxillofacial Surgery, National Clinical Research Centre for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. Electronic address: xudongwang70@hotmail.com.

Kaili Lin

Department of Oral & Cranio-Maxillofacial Surgery, National Clinical Research Centre for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. Electronic address: linkaili@sjtu.edu.cn.

References

PubMed