Researchers did this study to investigate the effect of fundus tracking perimetry on structure-function relationship in glaucoma.
The researchers included data from 696 eyes from 360 healthy people and 711 sights from 434 patients with glaucoma from the original study. The circum-papillary retinal nerve fiber layer optical coherence tomography scan was available. We explored the structure-function relationship using both global indices (mean deviation and average Cp-RNFL thickness loss) and anatomically defined visual field clusters comparing the R2 values from mixed-effect models. We then measured a combined Structure Function Index diagnostic ability using perimetric data from either perimeter.
The R2 for the global structure-function relationship was 0.50 for the CMP and 0.48 for the HFA. Overall, the discrimination ability of the SFI was not significantly higher than the Cp-RNFL for either the CMP or HFA. However, it was considerably better in eyes with perimetric damage, in which the CMP-SFI performed substantially better than the HFA-SFI (p=0.03).
The study concluded that the structure-function relationship is similar between the two perimeters. Fundus tracking might improve discrimination ability with a combined SFI.
Reference: https://bjo.bmj.com/content/104/12/1710
