IVC remains an important global salvage therapy for retinoblastoma. This study was done with the purpose to do an evaluation of long-term globe salvage at 5, 10, 15, and 20 years following frontline IVC for retinoblastoma.
Results obtained to the evaluation of 994 eyes, comparison by International Classification of Retinoblastoma group revealed a more advanced group with older mean age at presentation. By clinical features, the more advanced group demonstrated greater mean tumor diameter and thickness, and greater frequency of vitreous seeds ≥1 quadrant and subretinal seeds. By outcomes, the less advanced group demonstrated greater tumor control by year 2, and with a minimal change up to 20 years. In order to achieve globe salvage, additional IAC or plaque radiotherapy was employed by year 2, with little further need up to 20 years. Pinealoblastoma (2%), metastasis (2%) and death (1%) were infrequent.
The study concluded through its findings that the frontline IVC for retinoblastoma provided complete tumor control for groups A (96%), B (91%), C (91%), D (71%), and E (32%), avoiding enucleation or EBRT and was lasting for up to 20 years.
Reference: https://bjo.bmj.com/content/104/11/1548
