Indefinite anticoagulation for unprovoked venous thromboembolism is not cost-effective
Bookmark1. In this Markov modeling study, indefinite anticoagulation for first unprovoked venous...
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Emergency
Early versus late post-stroke anticoagulation in patients with atrial fibrillation results in similar outcomes
Bookmark1. In this randomized controlled trial of patients with atrial fibrillation who had an...
Read MoreLongitudinal data shows that the opioid epidemic may be worsening in Ontario, Canada
Bookmark1. In a cross-sectional study, rates of opioid-related deaths were observed to rise among youths in Ontario, Canada between 2013-2021, while the use of opioid agonist therapy declined. Evidence Rating Level: 2 (Good)...
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Supervised hospital walking program reduces the need for nursing care
Bookmark1. A supervised walking program was associated with reduced discharge rates to...
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Tirofiban is associated with better post-stroke outcomes than low-dose aspirin
Bookmark1. In this randomized controlled trial, tirofiban was associated with better outcomes than...
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High-definition cathodal direct current stimulation for treatment of acute ischemic stroke
Bookmark1. High-definition cathodal direct current stimulation (HD C-tDCS) is a feasible and...
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Craniotomy and decompressive craniectomy comparable in managing acute subdural hematoma
Bookmark1. In this randomized controlled trial, craniotomy and decompressive craniectomy resulted...
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Withholding prophylactic platelet transfusion in thrombocytopenia increases adverse events
Bookmark1. In this randomized controlled trial, withholding prophylactic platelet transfusion in...
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Hydrocortisone reduces mortality in severe community-acquired pneumonia
Bookmark1. Among patients with severe community-acquired pneumonia (CAP) admitted to the intensive...
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Ultrasonography noninferior to radiography for guiding pediatric fracture management
Bookmark1. In this randomized controlled trial, there was no difference in pediatric forearm...
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Lower rates of medication treatment for opioid use disorder in Black and Hispanic patients
Bookmark1. In this retrospective study of Medicare claims data from 2016 to 2019, receipt of...
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P2Y12 inhibitors not found to be effective for critically ill patients with COVID-19
Bookmark1. For critically ill patients hospitalized for COVID-19, P2Y12 inhibitors did not improve...
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There is substantial variation in the benefit of quality measures in acute stroke care
Bookmark1. In an acute stroke simulation, early carotid imaging and tissue plasminogen activator...
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Characterization of cancer development risk following pediatric radiation exposure from computed tomography
BookmarkEvidence rating level: 3 (Average) 1. Exposure to a higher cumulative number of pediatric...
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Endovascular therapy improved clinical outcomes among patients 6-24 hours post-ischemic stroke with collateral flow
Bookmark1. Median modified Rankin Scale score at 90 days was lower in the endovascular group,...
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Analysis of the role of positive end expiratory pressure for the cannulation of the subclavian vein
Bookmark1. Stepwise changes in positive end expiratory pressure (PEEP) were not associated with...
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Prophylactic tranexamic acid during cesarean section does not lower risk of mortality or transfusion
1. In this randomized controlled trial, prophylactic administration of tranexamic acid during...
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Bempedoic acid reduces the risk of major adverse cardiovascular events
1. In this randomized controlled trial, bempedoic acid significantly reduced low-density...
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Cerebral oximetry monitoring in extremely preterm infants does not reduce mortality
1. In this randomized controlled trial, 72 hours of cerebral oximetry monitoring in preterm...
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Propylthiouracil may be equivocal to methimazole for treatment of thyroid storm
1. In this multi-centre cohort study, there were no significant differences in mortality or...
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